INT184054

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 9.18
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Socs1)
Anatomy Link Frequency
liver 2
Socs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 365 100.00 Very High Very High Very High
fibrosis 12 99.64 Very High Very High Very High
Inflammation 277 98.60 Very High Very High Very High
Arthritis 24 92.28 High High
rheumatoid arthritis 64 90.32 High High
metalloproteinase 3 85.52 High High
cINOD 8 64.36 Quite High
addiction 3 63.40 Quite High
tolerance 58 60.72 Quite High
Crohn's disease 6 54.56 Quite High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 54 99.84 Very High Very High Very High
Cirrhosis 6 99.64 Very High Very High Very High
INFLAMMATION 275 98.60 Very High Very High Very High
Leukemia 9 98.52 Very High Very High Very High
Cancer 169 98.36 Very High Very High Very High
Infection 23 97.86 Very High Very High Very High
Hepatitis C Virus Infection 6 97.66 Very High Very High Very High
Autoimmune Disease 98 97.36 Very High Very High Very High
Hepatitis 32 97.36 Very High Very High Very High
Hematologic Neoplasms 6 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOCS1 may inhibit the development and/or progression of hepatocellular carcinoma (HCC), because SOCS1 expression is significantly reduced in HCC cells; this can be explained by the inactivation of the SOCS1 promoter due to hypermethylation of CpG islands [81,82].
Negative_regulation (reduced) of Gene_expression (expression) of SOCS1 associated with hepatocellular cancer
1) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.96 Pain Relevance 0.19
We found that SOCS1 gene silencing by DNA methylation is frequently observed in hepatitis induced by HCV infection [75], and SOCS1 gene methylation was well correlated with the severity of liver fibrosis, suggesting that decreasing SOCS1 gene expression by DNA methylation promotes liver inflammation.


Negative_regulation (decreasing) of Gene_expression (expression) of SOCS1 gene in liver associated with fibrosis, cirrhosis, inflammation, hepatitis c virus infection, infection and hepatitis
2) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.75 Pain Relevance 0.58
Recent reports have indicated that reduced expression and DNA methylation of SOCS1 are frequently found in myeloma and leukemia cells [92,93].
Negative_regulation (reduced) of Gene_expression (expression) of SOCS1 associated with leukemia
3) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.52 Pain Relevance 0.04
In STAT1-/- mice, gene expression of synovial SOCS1, but not that of SOCS3, was markedly reduced in STAT1-deficient mice.
Negative_regulation (reduced) of Gene_expression (expression) of SOCS1
4) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.71 Pain Relevance 0.70
The reduction of SOCS expression is also a therapeutic target. siRNA technology made the reduction of SOCS1 expression in DCs possible, and also improved anti-tumor immunity [69].
Spec (possible) Negative_regulation (made) of Gene_expression (expression) of SOCS1 associated with cancer
5) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.75 Pain Relevance 0.19
The reduction of SOCS expression is also a therapeutic target. siRNA technology made the reduction of SOCS1 expression in DCs possible, and also improved anti-tumor immunity [69].
Spec (possible) Negative_regulation (reduction) of Gene_expression (expression) of SOCS1 associated with cancer
6) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.75 Pain Relevance 0.19
miR-155 deficiency in Treg cells results in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of IL-2.
Negative_regulation (suppressor) of Gene_expression (expression) of SOCS1 associated with cytokine
7) Confidence 0.24 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.24 Pain Relevance 0.08
miR-155 deficiency in Treg cells results in increased suppressor of cytokine signaling 1 (SOCS1) expression accompanied by impaired activation of signal transducer and activator of transcription 5 (STAT5) transcription factor in response to limiting amounts of IL-2.
Negative_regulation (suppressor) of Gene_expression (expression) of cytokine signaling 1 associated with cytokine
8) Confidence 0.24 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.24 Pain Relevance 0.08
Most conspicuous is activation of the Jak/Stat pathway as indicated by elevated expression of Jak2 and Stat1, decreased expression of Socs1 and increased expression of several Stat target genes (Myc, Irf1, Igsf3g and Usp20) (Fig. 11A).
Negative_regulation (decreased) of Gene_expression (expression) of Socs1
9) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.25 Pain Relevance 0.11
This was not the result of widespread nonspecific degradation of TLR4-responsive kinases because endogenous levels of the TLR-responsive MAPK p38 were not reduced, even at the highest levels of transfected SOCS-1 (Fig. 5A, bottom).
Neg (not) Negative_regulation (reduced) of Gene_expression (levels) of SOCS-1
10) Confidence 0.09 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.06

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