INT184060

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 17.44
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
lung 6
skin 1
band 1
kidney 1
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 29 99.52 Very High Very High Very High
cytokine 240 97.56 Very High Very High Very High
Inflammation 374 97.08 Very High Very High Very High
fibrosis 106 95.64 Very High Very High Very High
Sciatic nerve 16 93.36 High High
Cannabinoid 11 90.56 High High
Arthritis 6 89.64 High High
dorsal root ganglion 55 88.08 High High
rheumatoid arthritis 11 87.68 High High
addiction 25 83.12 Quite High
Disease Link Frequency Relevance Heat
Cancer 1386 99.84 Very High Very High Very High
Skin Cancer 72 99.26 Very High Very High Very High
Targeted Disruption 75 99.20 Very High Very High Very High
Cold Sores 136 98.38 Very High Very High Very High
Metastasis 235 98.32 Very High Very High Very High
Viral Infection 2 98.00 Very High Very High Very High
Renal Cancer 12 97.96 Very High Very High Very High
INFLAMMATION 406 97.08 Very High Very High Very High
Dna Damage 120 97.08 Very High Very High Very High
Pulmonary Fibrosis 69 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of STAT1 by stable knockdown using small hairpin RNA (shRNA) leads to a reversion of the phenotype, decreased ability to form lung colonies and decreased resistance to genotoxic stress.
Negative_regulation (Suppression) of STAT1 in lung associated with dna damage
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.64 Pain Relevance 0.04
Most recently Hui et al [24] found overexpression of STAT1 in renal cell carcinoma relative to normal kidney cells and were subsequently able to radiosensitize tumor cells in vitro by suppressing STAT1 using siRNA or fludarabine.
Negative_regulation (suppressing) of STAT1 in kidney associated with cancer and renal cancer
2) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.70 Pain Relevance 0.03
Fryknas et al [22] reported similar effects when inhibiting STAT1 in myeloma cell lines by fludarabine with sensitization to both IR and Dox.
Negative_regulation (inhibiting) of STAT1
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.63 Pain Relevance 0.04
The gene array analysis in the present study detected greater than three-fold suppression of STAT1 and CXCL10 mRNA by 10 ?
Negative_regulation (suppression) of STAT1
4) Confidence 0.50 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.25 Pain Relevance 0.08
Based on our current observations we hypothesize that the decrease in nuclear pSTAT1 is primarily due to lower levels cytoplasmic STAT1 protein (Fig 5) that serves as the kinase substrate before translocation.
Negative_regulation (decrease) of pSTAT1
5) Confidence 0.44 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.28 Pain Relevance 0
These data demonstrate that STAT1 signaling is a key factor controlling the propensity for B16F1 melanoma cells to colonize the lung and that suppression of STAT1 can convert the tumor phenotype to poor lung colonizers.
Negative_regulation (suppression) of STAT1 in lung associated with cancer and skin cancer
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.65 Pain Relevance 0
Six-fold suppression of STAT1 with shRNA 24 led to a 4–5 fold suppression in lung colonization (Student's two-tailed t-test; p?
Negative_regulation (suppression) of STAT1 in lung
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.58 Pain Relevance 0
Previously, we showed that stable knockdown of STAT1 in IR-resistant and IFN?
Negative_regulation (knockdown) of STAT1
8) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.86 Pain Relevance 0
Four out of seven TSP genes (STAT1, IFIT1, IFIT3 and MX1) overlap with our five-gene IFN/STAT1-pathway marker set (see above).
Negative_regulation (seven) of STAT1
9) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.21 Pain Relevance 0
These cell lines showed negative IFN/STAT1 pathway expression scores ranging from ?
Negative_regulation (scores) of STAT1
10) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.07 Pain Relevance 0
First, the STAT1-dependent development of tumor clones with an increased propensity for lung colonization and resistance to IFN?
Negative_regulation (development) of STAT1 in lung associated with cancer
11) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.91 Pain Relevance 0
However, 12-fold suppression of STAT1 with shRNA 26 corresponded to a 56-fold suppression (Student's two-tailed t-test; p?
Negative_regulation (suppression) of STAT1
12) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.59 Pain Relevance 0
These results are consistent with our previous report, in which stable knockdown of STAT1 in nu61 (STAT1H genotype) led to radiosensitization both in vitro and in vivo [18].
Negative_regulation (knockdown) of STAT1
13) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.50 Pain Relevance 0.04
Stable knockdown of STAT1 reversed the aggressive phenotype and decreased both lung colonization and resistance to genotoxic stress.


Negative_regulation (knockdown) of STAT1 in lung associated with dna damage
14) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688034 Disease Relevance 0.93 Pain Relevance 0
Furthermore, data show that apigenin and luteolin treatments achieve these reductions through inactivation of STAT1 and suggest a mechanism whereby these compounds may prove to be an effective therapy for neurodegeneration.


Negative_regulation (inactivation) of STAT1
15) Confidence 0.38 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.49 Pain Relevance 0.23
A PEO-concentration dependent decrease of mRNA of C-X-C motif ligand 10 (a STAT1 responsive chemokine) and Interleukin 6 were also observed.


Negative_regulation (decrease) of STAT1 associated with chemokine
16) Confidence 0.37 Published 2010 Journal BMC Chem Biol Section Abstract Doc Link PMC2881005 Disease Relevance 0.79 Pain Relevance 0.21
PEO likely affects an intricate network of immune signaling genes including a novel concentration dependent reduction of total cellular Signal Transducer and Activator of Transcription 1 (STAT1) as well as nuclear phosphorylated-STAT1 (activated form of STAT1).
Negative_regulation (reduction) of STAT1
17) Confidence 0.37 Published 2010 Journal BMC Chem Biol Section Abstract Doc Link PMC2881005 Disease Relevance 0.83 Pain Relevance 0.21
Following western blot analysis of cell lysates, we found a decrease in STAT1 signaling in both flavonoid treatments as compared to positive control (Fig. 4 and 5).
Negative_regulation (decrease) of STAT1
18) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.14 Pain Relevance 0.10
Concentration dependent suppression of cytoplasmic STAT1 protein (Fig 5) and mRNA (data not shown) levels were observed.
Negative_regulation (suppression) of STAT1
19) Confidence 0.37 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.41 Pain Relevance 0.07
Quantification of band density revealed a 59% knockdown of TrpV1 protein in animals injected with HSV-GFP-miR-TRPV1 compared to the negative control, whereas the levels of TrpA1 and Stat1 were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Stat1 in band associated with cold sores
20) Confidence 0.36 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.34 Pain Relevance 0.38

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