INT184061

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.85
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat5a) nucleus (Stat5a) DNA binding (Stat5a)
cytoplasm (Stat5a) signal transducer activity (Stat5a)
Stat5a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 53 83.92 Quite High
Inflammation 35 41.12 Quite Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 45 98.42 Very High Very High Very High
Myelofibrosis 30 98.34 Very High Very High Very High
Apoptosis 21 98.20 Very High Very High Very High
Splenomegaly 4 92.24 High High
Syndrome 1 90.80 High High
Myelodysplastic Syndromes 38 88.48 High High
Lymphopenia 1 88.16 High High
Hepatotoxicity 1 82.56 Quite High
Targeted Disruption 11 76.56 Quite High
Disease 26 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These are consistent with our initial proposal that CIS is a negative regulator of STAT5 [11].
Negative_regulation (regulator) of STAT5
1) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.48 Pain Relevance 0.04
Treatment of CD34+ PMF-MPN cells with LBH589 induces apoptosis of PMF-MPN cells and inhibits the expression and activity of JAK2V617F with a subsequent reduction in p-STAT3, p-STAT5, p-AKT, p-GATA-1 and Bcl-xL [98].
Negative_regulation (reduction) of p-STAT5 associated with myeloproliferative disorder, apoptosis and myelofibrosis
2) Confidence 0.01 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.36 Pain Relevance 0

General Comments

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