INT184062

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.13
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
megakaryocytes 1
Jak2 (Mus musculus)
Jak2 - V617F (1)
Pain Link Frequency Relevance Heat
Crohn's disease 49 99.76 Very High Very High Very High
cytokine 100 96.84 Very High Very High Very High
cINOD 2 94.36 High High
fibrosis 8 78.16 Quite High
Inflammation 59 75.68 Quite High
rheumatoid arthritis 10 71.04 Quite High
cva 2 70.96 Quite High
Parenteral administration 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 94 99.76 Very High Very High Very High
Congenital Anomalies 20 99.64 Very High Very High Very High
Inflammatory Bowel Disease 57 99.36 Very High Very High Very High
Erythrocytosis 70 96.56 Very High Very High Very High
INFLAMMATION 58 94.12 High High
Reprotox - General 1 1 93.60 High High
Myelodysplastic Syndromes 124 92.04 High High
Hemorrhage 20 90.88 High High
Ileal Diseases 5 90.12 High High
Cancer 15 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We did not observe any obvious thrombotic events in our cohorts of polycythemic mice despite the significant elevation in hematocrit, and further studies will be necessary to determine if recipients of JAK2 V617F-transduced BM have abnormalities of coagulation.
JAK2 V617F-transduced (V617F) Binding (recipients) of associated with congenital anomalies
1) Confidence 0.37 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.52 Pain Relevance 0.04
When isolated after in vitro culture in thrombopoietin, megakaryocytes from JAK2 V617F recipients were noticeably smaller than their counterparts from normal mice or JAK2 WT recipients (Figure 3D), with many micromegakaryotes undergoing proplatelet formation and mitosis.
JAK2 Binding (recipients) of in megakaryocytes
2) Confidence 0.32 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.31 Pain Relevance 0.04
This 12-mer peptide interacts specifically with the autophosphorylation site of JAK2 and inhibits IFN-?
JAK2 Binding (interacts) of
3) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.79 Pain Relevance 0.07
Given that SNPs within CCR6, STAT3, JAK2, IL23R, IL12B, the IL22/IL26 and the IL2/IL21 gene cluster have been found to be associated with CD and or UC, we should take in mind the influence of these SNPs on Th17 cytokine profiles.
JAK2 Binding (associated) of associated with inflammatory bowel disease, crohn's disease and cytokine
4) Confidence 0.21 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.51 Pain Relevance 0.29
Indeed, co-immunoprecipitation assays demonstrated a constitutive interaction between JAK2 and the p85 subunit of PI3K (data not shown).
JAK2 Binding (interaction) of
5) Confidence 0.14 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03

General Comments

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