INT184068

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.03
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Socs1)
Anatomy Link Frequency
macrophages 2
T cells 1
Socs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 162 99.84 Very High Very High Very High
rheumatoid arthritis 21 99.62 Very High Very High Very High
Inflammation 117 98.20 Very High Very High Very High
Arthritis 8 92.96 High High
tolerance 129 87.12 High High
palliative 7 51.84 Quite High
cerebral cortex 2 44.88 Quite Low
substance P 4 43.28 Quite Low
anesthesia 2 42.88 Quite Low
Neuropeptide 1 33.16 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 21 99.62 Very High Very High Very High
Diabetes Mellitus 26 99.28 Very High Very High Very High
Sepsis 35 98.76 Very High Very High Very High
INFLAMMATION 117 98.20 Very High Very High Very High
Uveitis 1 97.12 Very High Very High Very High
Arthritis 12 93.76 High High
Hypersensitivity 8 92.96 High High
Multiple Sclerosis 4 92.32 High High
Disease 88 91.24 High High
Targeted Disruption 31 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This sequence of molecular events is associated with a marked induction of SOCS1, SOCS2, SOCS3, as well as cytokine-induced Src homology 2-containing protein expression.
Positive_regulation (induction) of SOCS1 associated with cytokine
1) Confidence 0.51 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.14 Pain Relevance 0.09
Blood CD4+ T cells from patients with rheumatoid arthritis (RA) contained higher levels of SOCS1 but lower levels of SOCS3 mRNA than control CD4+ T cells, as determined by real-time polymerase chain reaction [73].
Positive_regulation (levels) of SOCS1 in T cells associated with rheumatoid arthritis
2) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.17 Pain Relevance 0.59
SOCS1 and SOCS3 were found to be induced by LPS or CpG-DNA stimulation in macrophages [59-61].
Positive_regulation (induced) of SOCS1 in macrophages
3) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.85 Pain Relevance 0.23
We observed a striking dose-dependent reduction in basal PKR protein expression levels in response to an increase in SOCS-1 following 24 h of incubation (Fig. 5B, top).
Positive_regulation (increase) of SOCS-1
4) Confidence 0.15 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.05 Pain Relevance 0.12
Remarkably, PKR activity was dramatically enhanced and maximal in unstimulated SOCS-1?
Positive_regulation (maximal) of SOCS-1
5) Confidence 0.10 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.16 Pain Relevance 0.09
However, in tolerant macrophages, SOCS-1 levels were significantly elevated regardless of stimulus used (Fig. 5A).
Positive_regulation (elevated) of SOCS-1 in macrophages
6) Confidence 0.10 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.07 Pain Relevance 0.16
Several authors (Kovarik et al 2005; Stark and Cross 2006) found that SOCS-1 and SOCS-3 are induced by cytokines such as IFN?
Positive_regulation (induced) of SOCS-1 associated with cytokine
7) Confidence 0.09 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 0.37 Pain Relevance 0.46
Diabetic patients have a two-to-three times increased risk for SSI compared with non-diabetic patients after cardiac surgery [39].
Positive_regulation (increased) of SSI associated with diabetes mellitus
8) Confidence 0.08 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831242 Disease Relevance 0.90 Pain Relevance 0
The reason for this increased SSI risk could be due to the produced microscopic cuts, that later could serve as a foci for bacterial multiplication [17].
Positive_regulation (increased) of SSI
9) Confidence 0.08 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831242 Disease Relevance 0.31 Pain Relevance 0

General Comments

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