INT184077

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.69
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il3) extracellular region (Il3)
Anatomy Link Frequency
hematopoietic progenitor cells 1
cornea 1
Il3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 242 100.00 Very High Very High Very High
chemokine 54 100.00 Very High Very High Very High
Inflammatory response 20 97.72 Very High Very High Very High
Inflammation 352 90.16 High High
Inflammatory stimuli 13 82.68 Quite High
Neuropathic pain 18 82.40 Quite High
Calcitonin gene-related peptide 1 77.16 Quite High
Neuropeptide 1 75.88 Quite High
Kinase C 8 63.84 Quite High
Neuritis 1 54.68 Quite High
Disease Link Frequency Relevance Heat
Aspergillus Infection 1 98.10 Very High Very High Very High
INFLAMMATION 378 97.72 Very High Very High Very High
Keratitis 38 95.76 Very High Very High Very High
Pseudomonas Infection 1 91.80 High High
Encephalitis 1 91.24 High High
Cancer 310 88.72 High High
Disease 56 86.40 High High
Neuropathic Pain 19 82.40 Quite High
Repression 3 75.08 Quite High
Injury 19 74.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This family also includes IL-2, IL-3, IL-4, IL-6, IL-7, and IL-15.
Positive_regulation (includes) of IL-3
1) Confidence 0.06 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.59 Pain Relevance 0.23
Ectopic expression of HuR overcomes TTP-mediated destabilization of IL-3 mRNA and HuR mRNA in an ARE-dependent manner [69, 73].
Positive_regulation (destabilization) of IL-3 mRNA
2) Confidence 0.06 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.40 Pain Relevance 0.17
, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12p70, IL-17, GM-CSF, KC, and RANTES induction discriminate between the effects of BCG relative to the inflammatory responses obtained with LPS and TNF-?
Positive_regulation (induction) of IL-3 associated with chemokine and inflammatory response
3) Confidence 0.05 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.38 Pain Relevance 0.73
CIS is induced by cytokines that activate STAT5 and bind to receptors that activate STAT5, namely erythropoietin, IL-2, IL-3, prolactin and growth hormone (GH) [11].
Positive_regulation (activate) of IL-3 associated with cytokine
4) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.11 Pain Relevance 0.17
Wang and colleagues [10] exposed heat-killed spores of Aspergillus fumigatus to excised pieces of BALB/c mouse cornea and noted that several host genes were substantially upregulated including those encoding interleukin cytokines such as IL-3.
Positive_regulation (upregulated) of IL-3 in cornea associated with aspergillus infection and cytokine
5) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2562425 Disease Relevance 1.15 Pain Relevance 0.16
However, Runx1a may also have specific effects of its own, as evidenced by its ability to transactivate the interleukin-3 promoter (5) and enhance engraftment capacity of hematopoietic progenitor cells (6).
Positive_regulation (transactivate) of interleukin-3 promoter in hematopoietic progenitor cells
6) Confidence 0.03 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.22 Pain Relevance 0.19
The PI3 kinase pathway has been shown to be involved in the mRNA stabilization of several reporter genes linked to the ARE of IL-3, GM-CSF, TNF-?
Positive_regulation (stabilization) of IL-3
7) Confidence 0.02 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.85 Pain Relevance 0.36

General Comments

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