INT184094

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.49
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) signal transduction (Socs3) extracellular region (Il6)
cytoplasm (Socs3)
Anatomy Link Frequency
fibroblasts 3
Socs3 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 97.96 Very High Very High Very High
fibrosis 2 97.24 Very High Very High Very High
cytokine 50 93.48 High High
Arthritis 4 88.44 High High
rheumatoid arthritis 10 80.16 Quite High
Crohn's disease 1 60.92 Quite High
cINOD 1 36.08 Quite Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 97.96 Very High Very High Very High
Disease 20 97.44 Very High Very High Very High
Fibrosis 1 97.24 Very High Very High Very High
Hyperplasia 1 95.44 Very High Very High Very High
Experimental Arthritis 1 88.44 High High
Rheumatoid Arthritis 10 80.16 Quite High
Arthropathy 1 79.52 Quite High
Synovitis 1 77.56 Quite High
Adenoma 1 65.92 Quite High
Colitis 1 65.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of the evidence that forced expression of SOCS3 can inhibit IL-6-mediated STAT3 activation, we propose that SOCS3 is a negative regulator of inflammatory diseases in synovial fibroblasts, especially in those in which IL-6 levels are very high.
Gene_expression (expression) of SOCS3 in fibroblasts Negative_regulation (inhibit) of Positive_regulation (activation) of IL-6-mediated in fibroblasts associated with inflammation and disease
1) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.49 Pain Relevance 0.48

General Comments

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