INT184098

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.05
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4) cytoplasm (Socs5)
Anatomy Link Frequency
Th1 cells 1
Il4 (Mus musculus)
Socs5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 150 89.72 High High
Inflammation 102 29.56 Quite Low
rheumatoid arthritis 30 5.00 Very Low Very Low Very Low
Arthritis 12 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 33 94.32 High High
Diabetes Mellitus 6 92.80 High High
Obesity 9 92.28 High High
Metabolic Disorder 3 91.64 High High
Insulin Resistance 9 85.76 High High
Necrosis 6 78.40 Quite High
Cancer 39 78.04 Quite High
Weight Gain 3 65.60 Quite High
Body Weight 6 56.04 Quite High
Pathologic Processes 3 49.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOCS5 is expressed preferentially in Th1 cells and SOCS5 can interact with the IL-4 receptor in the absence of tyrosine phosphorylation.
IL-4 Binding (interact) of SOCS5 in Th1 cells
1) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.04 Pain Relevance 0
This interaction of SOCS5 with the IL-4 receptor is likely to cause the reduction in IL-4-induced activation of STAT6 and thus to regulate Th2 polarization.
IL-4 Binding (interaction) of SOCS5
2) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.01 Pain Relevance 0
SOCS5 has been shown to inhibit IL-4 signaling by interacting with the IL-4 receptor and inhibiting JAK1 binding to the receptor [15].
IL-4 Binding (interacting) of SOCS5
3) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0 Pain Relevance 0.15

General Comments

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