INT184100

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6) nucleolus (Stat1)
nucleus (Stat1) enzyme binding (Stat1) DNA binding (Stat1)
Anatomy Link Frequency
macrophages 1
Il6 (Mus musculus)
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 68 91.36 High High
cytokine 100 90.32 High High
rheumatoid arthritis 20 70.20 Quite High
Arthritis 8 34.16 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 6 91.68 High High
INFLAMMATION 62 91.36 High High
Rheumatoid Arthritis 20 70.20 Quite High
Disease 40 68.96 Quite High
Arthritis 12 34.16 Quite Low
Cancer 26 14.52 Low Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 18 5.00 Very Low Very Low Very Low
Hepatitis 10 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Others have shown that IL-6 strongly activates STAT1 and induces the expression of IFN-responsive genes in SOCS3-deficient macrophages, implying that IL-6 might mimic the action of IFNs [44,45].
IL-6 Positive_regulation (activates) of STAT1 in macrophages
1) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.38 Pain Relevance 0.24
uses JAK1 and JAK2, which activate mainly STAT1, whereas IL-6 binding to the IL-6 receptor ?
IL-6 Positive_regulation (activate) of STAT1
2) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.30 Pain Relevance 0.33

General Comments

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