INT184103

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
granulocyte 1
Socs3 (Mus musculus)
Il11ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 100 99.04 Very High Very High Very High
Inflammation 68 6.40 Low Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pathologic Processes 2 21.00 Low Low
Targeted Disruption 22 16.28 Low Low
INFLAMMATION 62 6.40 Low Low
Disease 40 5.36 Low Low
Cancer 26 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 20 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 18 5.00 Very Low Very Low Very Low
Arthritis 12 5.00 Very Low Very Low Very Low
Hepatitis 10 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although SOCS3 binds with a much higher affinity to a gp130 phosphopeptide around Tyr759 than to phospho-peptides derived from other receptors, such as leptin and erythropoietin receptors, multiple SOCS3-binding sites are predicted to exist in these receptors, which might compensate for weaker binding to individual sites.
SOCS3 Binding (binds) of gp130
1) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0 Pain Relevance 0.03
The SOCS3 SH2 domain has been shown to bind to Tyr757 of gp130, Tyr985 of the leptin receptor and Tyr401 of the erythropoietin receptor, Tyr729 of the granulocyte colony-stimulating factor (G-CSF) receptor, Tyr800 of the IL-12 receptor and Tyr985 of the leptin receptor, most being the same binding sites for protein tyrosine phosphatase 2 (SHP-2) [18-22].
SOCS3 Binding (bind) of gp130 in granulocyte
2) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0 Pain Relevance 0.13

General Comments

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