INT184105

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) extracellular space (Il6) extracellular region (Il6)
cytoplasm (Socs3)
Il6 (Mus musculus)
Socs3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 84 92.68 High High
Inflammation 42 80.32 Quite High
agonist 20 63.68 Quite High
tolerance 13 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 4 92.96 High High
Insulin Resistance 83 90.16 High High
INFLAMMATION 39 80.32 Quite High
Obesity 43 79.24 Quite High
Disease 22 77.08 Quite High
Shock 3 62.88 Quite High
Body Weight 4 58.96 Quite High
Cancer 15 48.44 Quite Low
Targeted Disruption 17 19.84 Low Low
Autoimmune Disease 1 18.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, IL-6 upregulated SOCS3, which could bind to IR on a key residue for the recognition of IRS-1, inhibiting its phosphorylation (16,44).
IL-6 Positive_regulation (upregulated) of SOCS3
1) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.49 Pain Relevance 0.03
Upregulation of socs3 by IL-6 was completely impaired by GW3965 and partially impaired by SP600125.
IL-6 Positive_regulation (Upregulation) of socs3
2) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.36 Pain Relevance 0.10
SOCS3 protein was strongly induced by both IL-6 and IL-10 in the presence of LPS, but selectively inhibited IL-6 signaling, because SOCS3 bound the IL-6 receptor, gp130 (Y759), but not the IL-10 receptor [43].
IL-6 Positive_regulation (induced) of SOCS3
3) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.49 Pain Relevance 0.34

General Comments

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