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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.14
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Socs3) cytoplasm (Tlr4, Socs3) plasma membrane (Tlr4)
intracellular (Tlr4)
Tlr4 (Mus musculus)
Socs3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 69 100.00 Very High Very High Very High
Inflammation 55 100.00 Very High Very High Very High
Inflammatory stimuli 3 100.00 Very High Very High Very High
Inflammatory mediators 3 61.72 Quite High
cINOD 5 60.08 Quite High
chemokine 8 29.16 Quite Low
Multiple sclerosis 1 26.48 Quite Low
rheumatoid arthritis 11 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 66 100.00 Very High Very High Very High
Neuroblastoma 1 80.88 Quite High
Death 3 79.36 Quite High
Disease 23 77.08 Quite High
Shock 3 65.52 Quite High
Drug Induced Neurotoxicity 3 55.20 Quite High
Cancer 15 48.44 Quite Low
Cognitive Disorder 2 43.28 Quite Low
Demyelinating Disease 1 26.48 Quite Low
Neurological Disease 1 25.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOCS3 is a negative modulator of inflammatory cytokine signaling [58] and can be induced by inflammatory stimuli such as LPS, TNF-?
LPS Positive_regulation (induced) of SOCS3 associated with inflammation, inflammatory stimuli and cytokine
1) Confidence 0.65 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.64 Pain Relevance 0.49
SOCS3 protein was strongly induced by both IL-6 and IL-10 in the presence of LPS, but selectively inhibited IL-6 signaling, because SOCS3 bound the IL-6 receptor, gp130 (Y759), but not the IL-10 receptor [43].
LPS Positive_regulation (induced) of SOCS3
2) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.50 Pain Relevance 0.34

General Comments

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