INT184116

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Il10) DNA binding (Stat3) cytoplasm (Stat3)
signal transducer activity (Stat3) cell proliferation (Stat3) signal transduction (Stat3)
Il10 (Mus musculus)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 76 99.98 Very High Very High Very High
Inflammation 70 99.80 Very High Very High Very High
rheumatoid arthritis 75 95.92 Very High Very High Very High
Arthritis 19 85.84 High High
chemokine 3 30.40 Quite Low
COX2 1 22.80 Low Low
antagonist 4 7.28 Low Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 76 99.80 Very High Very High Very High
Rheumatoid Arthritis 75 95.92 Very High Very High Very High
Arthritis 24 89.88 High High
Disease Progression 2 88.08 High High
Disease 44 62.36 Quite High
Autoimmune Disease 3 26.56 Quite Low
Apoptosis 2 25.28 Quite Low
Targeted Disruption 17 5.00 Very Low Very Low Very Low
Cancer 17 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the anti-inflammatory cytokine IL-10 also activates STAT3.
IL-10 Positive_regulation (activates) of STAT3 associated with inflammation and cytokine
1) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.29 Pain Relevance 0.43
IL-10 binds to the IL-10R1/IL-10R2 receptor complex and recruits both Jak1 and Tyk2 to activate STAT3 [125].
IL-10 Positive_regulation (activate) of STAT3
2) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.87 Pain Relevance 0.34

General Comments

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