INT184119

Context Info Confidence 0.21 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.64 Pain Relevance 0.08

extracellular space (Csf3) signal transduction (Socs3) extracellular region (Csf3) enzyme binding (Csf3) cytoplasm (Socs3)

Socs3 (Mus musculus) Csf3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 34 90.48 cytokine 50 50.00 rheumatoid arthritis 10 5.00 Arthritis 4 5.00 fibrosis 2 5.00 cerebral cortex 1 5.00 cINOD 1 5.00 tolerance 1 5.00 Crohn's disease 1 5.00

Disease Link Frequency Relevance Heat Coronary Heart Disease 1 94.52 INFLAMMATION 31 90.48 Tetraploidy 1 86.24 Embryonic Lethality 1 84.88 Splenomegaly 1 64.56 Hypertrophy 1 54.48 Paresis 1 54.32 Body Weight 2 52.20 Disease 20 43.40 Hepatotoxicity 1 17.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Conditional KO mice studies demonstrated that SOCS3 is an important negative regulator of IL-6 [43-45] and G-CSF [46,47].

SOCS3 Negative_regulation (regulator) of G-CSF

1) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.64 Pain Relevance 0.08

General Comments

This test has worked.