INT18412

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Context Info
Confidence 0.47
First Reported 1982
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 49
Total Number 51
Disease Relevance 17.82
Pain Relevance 10.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 50
plasma 1
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 254 100.00 Very High Very High Very High
cINOD 182 100.00 Very High Very High Very High
agonist 62 100.00 Very High Very High Very High
Serotonin 45 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
dopamine receptor 3 100.00 Very High Very High Very High
Clonidine 21 99.84 Very High Very High Very High
antagonist 68 99.74 Very High Very High Very High
Inflammation 178 99.40 Very High Very High Very High
headache 12 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 233 100.00 Very High Very High Very High
Heart Rate Under Development 23 99.96 Very High Very High Very High
Coagulation Disorder 34 99.70 Very High Very High Very High
Adhesions 105 99.64 Very High Very High Very High
Disease 162 99.50 Very High Very High Very High
Headache 28 99.32 Very High Very High Very High
Depression 62 99.20 Very High Very High Very High
Heparin-induced Thrombocytopenia 34 99.06 Very High Very High Very High
Cv General 3 Under Development 61 99.00 Very High Very High Very High
Suicidal Behaviour 10 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, some NSAIDs appear to interfere with the ability of aspirin to bind to platelet COX-1 and may therefore inhibit the antiplatelet effects of aspirin in patients taking both together.
platelet Binding (bind) of in platelet associated with aspirin and cinod
1) Confidence 0.47 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 0.47 Pain Relevance 0.66
Aspirin inhibits platelet aggregation by binding irreversibly to platelet COX-1, inhibiting the production of platelet thromboxane for the life of the platelet.
platelet Binding (binding) of in platelet associated with aspirin
2) Confidence 0.47 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 0.58 Pain Relevance 0.54
Following platelet rolling, the next escalation of platelet activation is also mediated by vWF, which, through firmly binding to the platelet GPIb receptor also mediates the first firm adhesion (Jackson et al 2003; Ruggeri 2003).
platelet Binding (binding) of in platelet associated with adhesions
3) Confidence 0.47 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515423 Disease Relevance 0.21 Pain Relevance 0.07
P-selectin expression was quantified as a binding index for platelet P-selectin (the percentage of positive platelets multiplied by the mean fluorescence of positive platelets).
platelet Binding (binding) of in platelets
4) Confidence 0.47 Published 2007 Journal Ther Apher Dial Section Abstract Doc Link 17661830 Disease Relevance 0.25 Pain Relevance 0.09
Platelet 3H ketanserin binding in tension-type headache.
Platelet Binding (binding) of in Platelet associated with headache
5) Confidence 0.47 Published 2003 Journal Headache Section Title Doc Link 12558763 Disease Relevance 0.10 Pain Relevance 0.19
OBJECTIVE: The present study was undertaken to investigate the alterations in platelet 5-HT2 receptor binding in patients with tension-type headache.
platelet Binding (binding) of in platelet associated with headache
6) Confidence 0.47 Published 2003 Journal Headache Section Abstract Doc Link 12558763 Disease Relevance 0.17 Pain Relevance 0.17
Characteristics of norepinephrine and clonidine displacement of [3H]yohimbine binding to platelet alpha2-adrenoreceptors in healthy volunteers.
platelet Binding (binding) of in platelet associated with clonidine
7) Confidence 0.47 Published 1999 Journal Psychiatry Res Section Title Doc Link 10333382 Disease Relevance 0.09 Pain Relevance 0.74
We wondered whether this inhibition might be mediated by an interaction of verapamil with platelet alpha-adrenergic receptors.
platelet Spec (might) Binding (interaction) of in platelet
8) Confidence 0.47 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 6277203 Disease Relevance 0 Pain Relevance 0.07
Interaction of verapamil with human platelet alpha-adrenergic receptors.
platelet Binding (Interaction) of in platelet
9) Confidence 0.47 Published 1982 Journal Am. J. Physiol. Section Title Doc Link 6277203 Disease Relevance 0 Pain Relevance 0.17
All these drugs therefore appear to interact with the same site on platelet cyclo-oxygenase.
platelet Binding (interact) of in platelet
10) Confidence 0.47 Published 1985 Journal Int J Tissue React Section Abstract Doc Link 3934097 Disease Relevance 0.16 Pain Relevance 0.28
Since abciximab binds to the platelet GP IIb-IIIa receptor with great avidity it has an extremely long biological half-life.
platelet Binding (binds) of in platelet
11) Confidence 0.47 Published 1999 Journal Drug Saf Section Abstract Doc Link 9935276 Disease Relevance 0 Pain Relevance 0.13
Our results indicate that (i) the stereochemical requirements for the interaction of catecholamines with platelet alpha 2-adrenoceptors are in agreement with the Easson-Stedman hypothesis and other alpha-adrenoceptor tissues; (ii) catecholamines lacking a benzylic hydroxyl group in the R-configuration and/or possessing an N-isopropyl group were alpha 2-adrenoceptor antagonists; (iii) clonidine gave quantitatively different responses compared with catecholamines for interaction with alpha 2-adrenoceptors; and (iv) inhibition of platelet adenylate cyclase is correlated to the inhibition of epinephrine-induced aggregation response for this series of compounds.
platelet Binding (interaction) of in platelet associated with antagonist, catecholamine and clonidine
12) Confidence 0.47 Published 1990 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2190233 Disease Relevance 0 Pain Relevance 0.58
These data agree with most previous studies, suggesting that a subset of platelet alpha 2 adrenoceptors, recognized by clonidine and its derivative para-aminoclonidine, is upregulated in depressed patients.
platelet Binding (recognized) of in platelet associated with clonidine
13) Confidence 0.47 Published 1990 Journal Neuropsychopharmacology Section Abstract Doc Link 1973039 Disease Relevance 0 Pain Relevance 0.14
BACKGROUND: Anti-inflammatory analgesics, including ibuprofen and naproxen, are known to interfere with the antiplatelet effect of aspirin, presumably as a result of a drug-drug interaction at the level of platelet cyclooxygenase-1 (COX-1).
platelet Binding (interaction) of in platelet associated with aspirin, inflammation and analgesic
14) Confidence 0.36 Published 2008 Journal J. Thromb. Haemost. Section Abstract Doc Link 17944992 Disease Relevance 0.10 Pain Relevance 0.31
Cluster 16 is a heterogeneous group of receptors binding to lipids, nucleotides, modified nucleotides and platelet activating factor (PAF).
platelet Binding (binding) of in platelet
15) Confidence 0.36 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0.08 Pain Relevance 0.03
Among these drugs picotamide attracted the attention of researchers for its ability to inhibit both TxA2 platelet synthase and platelet TxA2 receptors and, in turn, platelet aggregation.
platelet Binding (receptors) of in platelet
16) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.08 Pain Relevance 0.20
Characterization of platelet alpha 2 adrenoceptors and measurement in control and depressed subjects.
platelet Binding (Characterization) of in platelet
17) Confidence 0.36 Published 1985 Journal Psychiatry Res Section Title Doc Link 2986192 Disease Relevance 0 Pain Relevance 0.38
All modified p8 peptides showed reduced platelet binding. p8-A534 (cf III-30c) lost all binding, while p8-A546 (cf III-30b) retained best binding.
platelet Binding (binding) of in platelet
18) Confidence 0.36 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.05 Pain Relevance 0
The parallel measurement of TXB2 production during whole blood clotting is used as an index of platelet COX-1 activity (Patrono et al 1980).
platelet Binding (index) of in platelet associated with coagulation disorder
19) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.10 Pain Relevance 0.15
However, the finding of platelet-specific GP IIb/IIIa in lesions of MS patients [191] comes close to "Smoking-Gun" evidence of platelet involvement.
platelet Spec (finding) Binding (finding) of in platelet associated with multiple sclerosis and nicotine addiction
20) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 1.74 Pain Relevance 0.46

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