INT184120

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.39
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat6) extracellular space (Il4) extracellular region (Il4)
nucleus (Stat6) DNA binding (Stat6) cytoplasm (Stat6)
Anatomy Link Frequency
mesenchymal cell 1
Il4 (Mus musculus)
Stat6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 113 100.00 Very High Very High Very High
Inflammation 82 98.08 Very High Very High Very High
fibrosis 105 74.92 Quite High
rheumatoid arthritis 20 62.08 Quite High
chemokine 6 7.96 Low Low
Arthritis 9 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 16 99.08 Very High Very High Very High
INFLAMMATION 82 98.08 Very High Very High Very High
Respiratory Distress 1 94.04 High High
Targeted Disruption 28 93.12 High High
Lung Injury 7 91.20 High High
Hyperoxia 1 89.36 High High
Diabetes Mellitus 4 85.96 High High
Obesity 6 85.44 High High
Metabolic Disorder 2 84.80 Quite High
Insulin Resistance 6 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This interaction of SOCS5 with the IL-4 receptor is likely to cause the reduction in IL-4-induced activation of STAT6 and thus to regulate Th2 polarization.
IL-4 Positive_regulation (activation) of STAT6
1) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.93 Pain Relevance 0
STAT4 and STAT6 are essential for T helper (Th)1 and Th2 development, Because these are activated by IL-12 and IL-4, respectively.
IL-4 Positive_regulation (activated) of STAT6
2) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.28 Pain Relevance 0.48
STAT-6 is activated by Th2 cytokines such as IL-13 and IL-4, but not by polypeptide growth factors such as PDGF and EGF that mediate mesenchymal cell survival.
IL-4 Positive_regulation (activated) of STAT-6 in mesenchymal cell associated with cytokine
3) Confidence 0.03 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 1.18 Pain Relevance 0.19

General Comments

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