INT184124

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.40
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) signal transduction (Socs3) extracellular region (Il6)
cytoplasm (Socs3)
Anatomy Link Frequency
macrophages 1
Socs3 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 100 89.12 High High
Inflammation 68 89.04 High High
Arthritis 8 55.60 Quite High
rheumatoid arthritis 20 44.24 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 2 94.52 High High
INFLAMMATION 62 89.04 High High
Tetraploidy 2 86.24 High High
Embryonic Lethality 2 84.88 Quite High
Shock 6 82.12 Quite High
Disease 40 68.56 Quite High
Splenomegaly 2 63.12 Quite High
Arthritis 12 55.60 Quite High
Hypertrophy 2 54.48 Quite High
Paresis 2 52.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conditional KO mice studies demonstrated that SOCS3 is an important negative regulator of IL-6 [43-45] and G-CSF [46,47].
SOCS3 Regulation (regulator) of IL-6
1) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.64 Pain Relevance 0.07
Interestingly, these reports also demonstrated that the absence of SOCS3 in macrophages changes the original function of IL-6.
SOCS3 Regulation (changes) of IL-6 in macrophages
2) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.76 Pain Relevance 0.36

General Comments

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