INT184125

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Il12a, Stat4) cell proliferation (Stat4) signal transduction (Stat4)
extracellular space (Il12a) extracellular region (Il12a) nucleus (Stat4)
Il12a (Mus musculus)
Stat4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 44 99.64 Very High Very High Very High
cytokine 73 98.84 Very High Very High Very High
Inflammation 69 98.48 Very High Very High Very High
Multiple sclerosis 24 73.60 Quite High
rheumatoid arthritis 10 62.48 Quite High
Central nervous system 47 59.28 Quite High
Spinal cord 6 5.00 Very Low Very Low Very Low
Demyelination 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 72 98.48 Very High Very High Very High
Multiple Sclerosis 36 97.28 Very High Very High Very High
Disease 79 87.72 High High
Autoimmune Disease 5 84.96 Quite High
Demyelinating Disease 30 73.60 Quite High
Targeted Disruption 17 63.76 Quite High
Rheumatoid Arthritis 10 62.48 Quite High
Stroke 13 61.04 Quite High
Central Nervous System Disease 5 9.88 Low Low
Cancer 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-12-induced tyrosine phosphorylation of Jak2, Tyk2, Stat3, and Stat4 in T
IL-12-induced Positive_regulation (induced) of Stat4
1) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.76 Pain Relevance 0.22
STAT4 and STAT6 are essential for T helper (Th)1 and Th2 development, Because these are activated by IL-12 and IL-4, respectively.
IL-12 Positive_regulation (activated) of STAT4
2) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.28 Pain Relevance 0.48

General Comments

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