INT18413

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.06
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 6
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 5 100.00 Very High Very High Very High
Catecholamine 5 100.00 Very High Very High Very High
Potency 2 92.28 High High
antagonist 14 89.80 High High
cva 60 83.00 Quite High
depression 1 77.12 Quite High
Dopamine 4 67.24 Quite High
agonist 2 59.12 Quite High
Parenteral administration 1 43.92 Quite Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 7 96.56 Very High Very High Very High
Syndrome 8 91.52 High High
Thrombosis Related Under Development 48 91.16 High High
Cv General 3 Under Development 23 83.00 Quite High
Hemorrhage 27 78.00 Quite High
Stroke 32 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 30 5.00 Very Low Very Low Very Low
Thrombosis 24 5.00 Very Low Very Low Very Low
Acute Coronary Syndrome 15 5.00 Very Low Very Low Very Low
Myocardial Infarction 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data agree with most previous studies, suggesting that a subset of platelet alpha 2 adrenoceptors, recognized by clonidine and its derivative para-aminoclonidine, is upregulated in depressed patients.
Positive_regulation (upregulated) of platelet Binding (recognized) of in platelet associated with clonidine
1) Confidence 0.49 Published 1990 Journal Neuropsychopharmacology Section Abstract Doc Link 1973039 Disease Relevance 0 Pain Relevance 0.14
Our results indicate that (i) the stereochemical requirements for the interaction of catecholamines with platelet alpha 2-adrenoceptors are in agreement with the Easson-Stedman hypothesis and other alpha-adrenoceptor tissues; (ii) catecholamines lacking a benzylic hydroxyl group in the R-configuration and/or possessing an N-isopropyl group were alpha 2-adrenoceptor antagonists; (iii) clonidine gave quantitatively different responses compared with catecholamines for interaction with alpha 2-adrenoceptors; and (iv) inhibition of platelet adenylate cyclase is correlated to the inhibition of epinephrine-induced aggregation response for this series of compounds.
Positive_regulation (requirements) of platelet Binding (interaction) of in platelet associated with antagonist, catecholamine and clonidine
2) Confidence 0.49 Published 1990 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2190233 Disease Relevance 0 Pain Relevance 0.59
This condition develops as the result of the formation of antibodies to the heparin-platelet factor 4 complex, which causes secondary activation of platelets, coagulation, and ultimately increased thrombin production.33
Positive_regulation (increased) of platelet Binding (complex) of in platelets
3) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 1.06 Pain Relevance 0.04

General Comments

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