INT184137

Context Info Confidence 0.09 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.01 Pain Relevance 0

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2) protein complex (Hand2) transcription factor binding (Hand2) cytoplasm (Socs5)

Socs5 (Mus musculus) Hand2 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 50 50.00 Inflammation 34 25.92 rheumatoid arthritis 10 5.00 Arthritis 4 5.00 fibrosis 2 5.00 cerebral cortex 1 5.00 cINOD 1 5.00 tolerance 1 5.00 Crohn's disease 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 11 95.12 Diabetes Mellitus 2 89.16 Obesity 3 88.64 Metabolic Disorder 1 88.00 Insulin Resistance 3 82.12 Necrosis 2 74.76 Cancer 13 74.40 Weight Gain 1 61.96 Body Weight 2 52.40 Paresis 1 29.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This interaction of SOCS5 with the IL-4 receptor is likely to cause the reduction in IL-4-induced activation of STAT6 and thus to regulate Th2 polarization.

SOCS5 Binding (interaction) of Regulation (regulate) of Th2

1) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.01 Pain Relevance 0

General Comments

This test has worked.