INT184142

Context Info Confidence 0.02 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.48 Pain Relevance 0.35

extracellular space (Il6, TNF) extracellular region (Il6, TNF) signal transduction (TNF) plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)

Anatomy Link Frequency macrophages 2 Il6 (Mus musculus) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 50 94.72 Inflammation 34 82.36 rheumatoid arthritis 10 5.00 Arthritis 4 5.00 fibrosis 2 5.00 cerebral cortex 1 5.00 cINOD 1 5.00 tolerance 1 5.00 Crohn's disease 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 31 82.36 Disease 20 79.12 Shock 3 57.52 Cancer 13 50.48 Targeted Disruption 11 21.88 Autoimmune Disease 1 20.40 Rheumatoid Arthritis 10 5.00 Hepatocellular Cancer 9 5.00 Arthritis 6 5.00 Hepatitis 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In macrophages lacking the SOCS3 gene, or carrying a mutation of the SOCS3 binding site (Y759F) in gp130, not only IL-10 but also IL-6 suppressed LPS-induced TNF-?

IL-6 Negative_regulation (suppressed) of Positive_regulation (induced) of TNF in macrophages

1) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.48 Pain Relevance 0.35

General Comments

This test has worked.