INT184142

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, TNF) extracellular region (Il6, TNF) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 2
Il6 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 50 94.72 High High
Inflammation 34 82.36 Quite High
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 82.36 Quite High
Disease 20 79.12 Quite High
Shock 3 57.52 Quite High
Cancer 13 50.48 Quite High
Targeted Disruption 11 21.88 Low Low
Autoimmune Disease 1 20.40 Low Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 9 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Hepatitis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In macrophages lacking the SOCS3 gene, or carrying a mutation of the SOCS3 binding site (Y759F) in gp130, not only IL-10 but also IL-6 suppressed LPS-induced TNF-?
IL-6 Negative_regulation (suppressed) of Positive_regulation (induced) of TNF in macrophages
1) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.48 Pain Relevance 0.35

General Comments

This test has worked.

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