INT184154

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.40
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
chondrocytes 1
finger 1
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 99.84 Very High Very High Very High
dexamethasone 3 99.78 Very High Very High Very High
Osteoarthritis 3 98.92 Very High Very High Very High
cytokine 28 98.84 Very High Very High Very High
Inflammation 122 98.76 Very High Very High Very High
rheumatoid arthritis 21 98.24 Very High Very High Very High
Central nervous system 9 97.20 Very High Very High Very High
cINOD 19 93.28 High High
Intracerebroventricular 3 92.72 High High
Arthritis 36 87.04 High High
Disease Link Frequency Relevance Heat
Pain 6 99.84 Very High Very High Very High
Osteoarthritis 9 98.92 Very High Very High Very High
INFLAMMATION 122 98.76 Very High Very High Very High
Rheumatoid Arthritis 24 98.24 Very High Very High Very High
Fever 12 91.52 High High
Osteoporosis 3 88.72 High High
Hypercalcemia 7 87.92 High High
Arthritis 36 87.04 High High
Inflammatory Pain 3 74.56 Quite High
Neuropathic Pain 3 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was recently shown that the zinc-finger-containing transcription factor, early growth response gene-1 (Egr-1) binds specifically to GC-rich elements in the mPGES-1 promoter region and facilitates murine mPGES-1 gene transcription [28].
Transcription (transcription) of mPGES-1 in finger
1) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.15 Pain Relevance 0.11
Studies also describe mPGES-1 in pain models. mPGES-1 null mice exhibit diminished writhing in response to intraperitoneal injections of acetic acid (especially after LPS priming [11]), similar to NSAID-treated wild-type mice [16].
Transcription (describe) of mPGES-1 associated with pain and cinod
2) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.18 Pain Relevance 0.90
In studies examining rheumatoid arthritis synovial cells and osteoarthritis chondrocytes, treatment with dexamethasone decreased mPGES-1 mRNA and protein expression mediated by proinflammatory cytokines [23,25,27].
Transcription (expression) of mPGES-1 in chondrocytes associated with rheumatoid arthritis, dexamethasone, osteoarthritis and cytokine
3) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.96 Pain Relevance 0.66
The mRNA expression of mPGES-1, mPGES-2, cPGES and COX-2, as measured by oligonucleotide microarray, is seen in Figure 2.
Transcription (expression) of mPGES-1
4) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.05 Pain Relevance 0.03
The mRNA expression of mPGES-1, mPGES-2, cPGES and COX-2, as measured by oligonucleotide microarray, is seen in Figure 2.
Transcription (expression) of mPGES-2
5) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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