INT184157

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.93
Pain Relevance 0.71

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unfolded protein binding (Ptges3) cell proliferation (Ptges3) nucleus (Ptges3)
cytoplasm (Ptges3)
Anatomy Link Frequency
muscle tissue 1
colon 1
muscle 1
vessels 1
lung 1
Ptges3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 8 96.04 Very High Very High Very High
Inflammation 131 95.00 High High
Pain 10 85.64 High High
Arthritis 15 53.24 Quite High
cINOD 29 50.48 Quite High
COX-2 inhibitor 11 43.76 Quite Low
cytokine 31 43.60 Quite Low
Inflammatory response 7 40.00 Quite Low
chemokine 8 30.84 Quite Low
rheumatoid arthritis 9 22.32 Low Low
Disease Link Frequency Relevance Heat
Myositis 81 96.04 Very High Very High Very High
INFLAMMATION 152 95.72 Very High Very High Very High
Cancer 163 87.00 High High
Cyst 11 86.32 High High
Pain 10 85.64 High High
Stomach Cancer 6 82.56 Quite High
Malignant Neoplastic Disease 44 65.60 Quite High
Ovarian Cancer 42 65.60 Quite High
Colon Cancer 75 60.48 Quite High
Arthritis 15 53.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of cPGES and mPGES-2 mRNA was not significantly different between COX-2+/+ and COX-2-/- mice after LPS injection (data not shown), suggesting that these enzymes are not involved in the enhanced neuroinflammatory response of COX-2-/- mice at the time point examined.


Spec (examined) Gene_expression (expression) of cPGES
1) Confidence 0.45 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.07 Pain Relevance 0.03
Cytosolic PGES (cPGES) is constitutively expressed in a wide variety of mammalian cell lines and tissues and is not responsive to stimulation with bacterial lipopolysaccharide (LPS) [7].
Gene_expression (expressed) of cPGES
2) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.11 Pain Relevance 0.08
This is in contrast to the two other known members of this family, mPGES-2 and cPGES, which are constitutively expressed in various cells and tissues [50].
Gene_expression (expressed) of cPGES
3) Confidence 0.32 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.71 Pain Relevance 0.05
After treatment the COX-2 positive cells in muscle tissue were significantly decreased, while the expression of mPGES-1, cPGES or COX-1 was not suppressed.
Gene_expression (expression) of cPGES in muscle tissue
4) Confidence 0.21 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.50 Pain Relevance 0.21
Staining of cPGES was observed in scattered mononuclear cells, cells surrounding large vessels and muscle fibres in myositis and healthy muscle tissues with a similar distribution pattern (data not shown).
Gene_expression (Staining) of cPGES in muscle associated with myositis
5) Confidence 0.19 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.35 Pain Relevance 0.04
PGH2, which is synthesized by the action of COX-2, is isomerized to PGE2 by terminal prostaglandin E synthase (PGES), and multiple isoforms of terminal PGES have so far been identified.12,16 The cytosolic PGES (cPGES) is constitutively expressed and functionally coupled to COX-1,17 whereas the microsomal prostaglandin E synthase-1 (mPGES-1) is rapidly induced by various stimuli in a COX-2 expression-related manner.12,16 The physiologic relevance of mPGES-1 expression in vivo has been substantiated recently by the finding that mPGES-1-deficient mice display attenuated responses to inflammation and pain.19 Furthermore, mPGES-1 is constitutively expressed in colon, lung, and gastric cancers,20-22 suggesting that it participates in tumorigenesis.
Gene_expression (expressed) of cPGES in lung associated with pain, inflammation and stomach cancer
6) Confidence 0.16 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.42 Pain Relevance 0.13
Staining of cPGES was observed in scattered mononuclear cells, cells surrounding large vessels and muscle fibres in myositis and healthy muscle tissues with a similar distribution pattern (data not shown).
Gene_expression (Staining) of cPGES in vessels associated with myositis
7) Confidence 0.06 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0.35 Pain Relevance 0.04
PGH2, which is synthesized by the action of COX-2, is isomerized to PGE2 by terminal prostaglandin E synthase (PGES), and multiple isoforms of terminal PGES have so far been identified.12,16 The cytosolic PGES (cPGES) is constitutively expressed and functionally coupled to COX-1,17 whereas the microsomal prostaglandin E synthase-1 (mPGES-1) is rapidly induced by various stimuli in a COX-2 expression-related manner.12,16 The physiologic relevance of mPGES-1 expression in vivo has been substantiated recently by the finding that mPGES-1-deficient mice display attenuated responses to inflammation and pain.19 Furthermore, mPGES-1 is constitutively expressed in colon, lung, and gastric cancers,20-22 suggesting that it participates in tumorigenesis.
Gene_expression (expressed) of cPGES in colon associated with pain, inflammation and stomach cancer
8) Confidence 0.05 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.42 Pain Relevance 0.13

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