INT184191

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.59
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (IL1B) carbohydrate metabolic process (SPAM1) cell-cell signaling (IL1B)
cytosol (IL1B) extracellular space (IL1B) signal transduction (IL1B)
Anatomy Link Frequency
connective tissue 2
IL1B (Homo sapiens)
SPAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 71.48 Quite High
cINOD 2 68.68 Quite High
cytokine 16 59.92 Quite High
rheumatoid arthritis 2 19.44 Low Low
fibrosis 6 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthropathy 2 77.20 Quite High
INFLAMMATION 22 71.48 Quite High
Wound Healing 2 65.28 Quite High
Cancer 8 61.84 Quite High
Metastasis 4 60.40 Quite High
Adhesions 4 21.04 Low Low
Rheumatoid Arthritis 2 19.44 Low Low
Advanced Or Metastatic Breast Cancer 2 19.04 Low Low
Arthritis 6 18.28 Low Low
Hypersensitivity 12 11.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, and importantly, IL-1 enhanced PH-20 levels not only in cell layer extracts but also in culture media of the three cell lines.
IL-1 Positive_regulation (enhanced) of Gene_expression (levels) of PH-20
1) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.06 Pain Relevance 0.06
Our study provides strong evidence that connective tissue cells express PH-20 and that the production of this neutral-active hyaluronidase is up-regulated by IL-1.
IL-1 Positive_regulation (regulated) of Gene_expression (production) of PH-20 in connective tissue
2) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.53 Pain Relevance 0.17

General Comments

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