INT184192

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.49
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (IL1B) carbohydrate metabolic process (SPAM1) cell-cell signaling (IL1B)
cytosol (IL1B) extracellular space (IL1B) signal transduction (IL1B)
IL1B (Homo sapiens)
SPAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 96.16 Very High Very High Very High
metalloproteinase 4 75.20 Quite High
cytokine 16 59.36 Quite High
chemokine 2 58.16 Quite High
fibrosis 6 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 8 97.64 Very High Very High Very High
INFLAMMATION 22 96.16 Very High Very High Very High
Arthritis 6 73.36 Quite High
Urticaria 2 30.08 Quite Low
Advanced Or Metastatic Breast Cancer 2 18.48 Low Low
Cicatrix 2 15.36 Low Low
Injury 8 12.48 Low Low
Hypersensitivity 12 5.00 Very Low Very Low Very Low
Fibrosis 6 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, since PH-20 activity is enhanced by IL-1, the hyaluronidase may also contribute to the production of HA fragments that accumulate under inflammatory conditions and act as signaling molecules.
IL-1 Positive_regulation (enhanced) of PH-20 associated with inflammation
1) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.43 Pain Relevance 0.18
Further, and importantly, IL-1 enhanced PH-20 levels not only in cell layer extracts but also in culture media of the three cell lines.
IL-1 Positive_regulation (enhanced) of PH-20
2) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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