INT184193

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.12
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS, IL1B) signal transduction (HRAS, IL1B) aging (IL1B)
Golgi apparatus (HRAS) GTPase activity (HRAS) cell-cell signaling (IL1B)
Anatomy Link Frequency
macrophages 4
dendritic cells 1
eosinophils 1
HRAS (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 98.76 Very High Very High Very High
Inflammation 30 97.06 Very High Very High Very High
Osteoarthritis 9 91.44 High High
cytokine 24 50.64 Quite High
fibrosis 9 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 97.06 Very High Very High Very High
Osteoarthritis 9 91.44 High High
Arthritis 9 89.44 High High
Disease 6 11.72 Low Low
Hypersensitivity 18 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Fibrosis 9 5.00 Very Low Very Low Very Low
Chondrosarcoma 9 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in vitro have also indicated that HA fragments similar in size to that of fragmented HA molecules found in vivo in inflammatory sites induce the expression of inflammatory genes in dendritic cells, macrophages, eosinophils, and certain epithelial cells [7]; this effect is in contrast to that of high-molecular-weight HA molecules, which inhibit the production of IL-1, prostaglandin E2, and matrix metalloproteinases [10-12].
HA Negative_regulation (inhibit) of Gene_expression (production) of IL-1 in macrophages associated with inflammation and metalloproteinase
1) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.37 Pain Relevance 0.22
Studies in vitro have also indicated that HA fragments similar in size to that of fragmented HA molecules found in vivo in inflammatory sites induce the expression of inflammatory genes in dendritic cells, macrophages, eosinophils, and certain epithelial cells [7]; this effect is in contrast to that of high-molecular-weight HA molecules, which inhibit the production of IL-1, prostaglandin E2, and matrix metalloproteinases [10-12].
HA Negative_regulation (inhibit) of in dendritic cells Gene_expression (production) of IL-1 in macrophages associated with inflammation and metalloproteinase
2) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.37 Pain Relevance 0.22
Studies in vitro have also indicated that HA fragments similar in size to that of fragmented HA molecules found in vivo in inflammatory sites induce the expression of inflammatory genes in dendritic cells, macrophages, eosinophils, and certain epithelial cells [7]; this effect is in contrast to that of high-molecular-weight HA molecules, which inhibit the production of IL-1, prostaglandin E2, and matrix metalloproteinases [10-12].
HA Negative_regulation (inhibit) of in eosinophils Gene_expression (production) of IL-1 in macrophages associated with inflammation and metalloproteinase
3) Confidence 0.00 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.37 Pain Relevance 0.22

General Comments

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