INT184208

Context Info Confidence 0.32 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.03

signal transduction (IL1B, SOX9) aging (IL1B) extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9) cell-cell signaling (IL1B)

IL1B (Homo sapiens) SOX9 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 6 61.68 metalloproteinase 9 5.00 cytokine 6 5.00 antagonist 5 5.00 backache 4 5.00 Chronic low back pain 2 5.00 Osteoarthritis 2 5.00 Inflammation 1 5.00 Pain 1 5.00 Sciatica 1 5.00

Disease Link Frequency Relevance Heat Volume Depletion And Dehydration 1 48.40 Intervertebral Disk Degeneration 7 5.00 Low Back Pain 6 5.00 Disease 3 5.00 Death 2 5.00 Necrosis 2 5.00 Cancer 2 5.00 Osteoarthritis 2 5.00 Intervertebral Disk Displacement 2 5.00 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SOX6 (usually in combination with SOX9, which was also decreased by IL-1 [albeit not significantly] in this study) determines the chondrogenic phenotype [52].

IL-1 Negative_regulation (decreased) of SOX9

1) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.