INT184216

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.76
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS5) extracellular region (ADAMTS5) proteinaceous extracellular matrix (ADAMTS5)
Anatomy Link Frequency
chondrocyte 2
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 194 95.52 Very High Very High Very High
Inflammation 90 93.48 High High
metalloproteinase 12 89.92 High High
cytokine 29 89.64 High High
cINOD 34 74.72 Quite High
Arthritis 8 66.60 Quite High
depression 1 62.88 Quite High
Pain 39 50.00 Quite Low
Analgesic 3 21.68 Low Low
aspirin 9 15.92 Low Low
Disease Link Frequency Relevance Heat
Cancer 11 98.40 Very High Very High Very High
Necrosis 7 98.12 Very High Very High Very High
Osteoarthritis 193 95.52 Very High Very High Very High
INFLAMMATION 95 93.48 High High
Disease 50 76.72 Quite High
Disease Progression 8 70.64 Quite High
Arthritis 15 66.60 Quite High
Depression 1 62.88 Quite High
Neurodegenerative Disease 2 62.28 Quite High
Steatorrhea 1 56.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cells derived from the non-degenerate discs, a slight, nonsignificant decrease in aggrecanase gene expression was observed (Fig. 4c,d).


Negative_regulation (decrease) of Gene_expression (expression) of aggrecanase gene
1) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
Although no true selective inhibitor of aggrecanase has been reported, efforts to discover tumour necrosis factor-?
Neg (no) Negative_regulation (inhibitor) of Neg (no) Gene_expression (selective) of aggrecanase associated with necrosis and cancer
2) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.65 Pain Relevance 0.19
When EPA and DHA are incorporated into articular cartridge chondrocyte cell membranes, there is a dose-dependent decrease in the expression and activity of the proteoglycan-degrading aggrecanase enzymes.[1223–25275085]
Negative_regulation (decrease) of Gene_expression (expression) of aggrecanase in chondrocyte
3) Confidence 0.01 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 1.11 Pain Relevance 0.61

General Comments

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