INT184217

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Title
Documents 2
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS5) extracellular region (ADAMTS5) proteinaceous extracellular matrix (ADAMTS5)
Anatomy Link Frequency
tendon 4
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 25 95.64 Very High Very High Very High
Pain 29 80.20 Quite High
cytokine 28 43.32 Quite Low
agonist 6 41.12 Quite Low
antagonist 5 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Chronic low back pain 2 5.00 Very Low Very Low Very Low
Mechanotransduction 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tendinopathy 20 79.88 Quite High
Volume Depletion And Dehydration 1 67.92 Quite High
Intervertebral Disk Degeneration 7 27.24 Quite Low
Rupture 8 5.00 Very Low Very Low Very Low
Low Back Pain 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADAMTS-5 gene expression was not significantly altered by IL-1 treatment.
Neg (not) Regulation (altered) of Gene_expression (expression) of ADAMTS-5
1) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.07 Pain Relevance 0
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells
Regulation (regulation) of Gene_expression (expression) of aggrecanase in tendon
2) Confidence 0.09 Published 2008 Journal Matrix Biol Section Title Doc Link PMC2443387 Disease Relevance 0.15 Pain Relevance 0.20
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells
Regulation (regulation) of Gene_expression (expression) of aggrecanase in tendon
3) Confidence 0.03 Published 2008 Journal Matrix Biol Section Title Doc Link PMC2443387 Disease Relevance 0.15 Pain Relevance 0.20

General Comments

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