INT184220

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.58
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9)
extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)
Anatomy Link Frequency
chondrocytes 4
SOX9 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 13 94.40 High High
Inflammation 32 5.00 Very Low Very Low Very Low
Osteoarthritis 20 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
rheumatoid arthritis 18 5.00 Very Low Very Low Very Low
metalloproteinase 13 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
backache 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 1 97.48 Very High Very High Very High
Disease 37 86.68 High High
Intervertebral Disk Degeneration 46 76.00 Quite High
Peripheral Arterial Disease 51 73.52 Quite High
Spinal Osteophytosis 2 10.96 Low Low
INFLAMMATION 60 5.00 Very Low Very Low Very Low
Osteoarthritis 23 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 18 5.00 Very Low Very Low Very Low
Low Back Pain 10 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gruber et al considered that loss of expression of Sox9 in some of the anulus cell population may play a role in disc aging and degeneration, possibly by decreased modulation of the expression and production of Type II collagen of disc cells 36.
Negative_regulation (loss) of Gene_expression (expression) of Sox9 associated with aging
1) Confidence 0.36 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.37 Pain Relevance 0
IL-1 treatment of cells derived from non-degenerate discs resulted in a decrease in both SOX6 and SOX9 gene expression.
Negative_regulation (decrease) of Gene_expression (expression) of SOX9
2) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
In monolayer culture, the expression of genes characteristic of chondrocytes, such as aggrecan, collagen type II, IX, and XI, SOX5, and SOX9, was significantly lower in cells expanded with FGF-2 compared with those without (P < 0.05) (Figure 5).
Negative_regulation (lower) of Gene_expression (expression) of SOX9 in chondrocytes
3) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.21 Pain Relevance 0
RT-PCR also showed that expression of type II collagen and SOX-9 was reduced (Fig. 1B).
Negative_regulation (reduced) of Gene_expression (expression) of SOX-9
4) Confidence 0.09 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693859 Disease Relevance 0 Pain Relevance 0
Under these experimental conditions 15d-PGJ2 displayed no cytotoxicity, as assessed by the conversion of a tetrazolium compound to its formazan product, as well as trypan blue exclusion (data not shown). 15d-PGJ2 inhibited type II collagen, a marker for differentiation of chondrocytes, and SOX-9 expression, a major transcription factor that regulates type II collagen expression, in a dose- and time-dependent manner as determined by immunoblot analysis (Fig. 1A).
Negative_regulation (inhibited) of Gene_expression (expression) of SOX-9 in chondrocytes
5) Confidence 0.07 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693859 Disease Relevance 0 Pain Relevance 0
activation is associated with dedifferentiation and/or COX-2 expression and PGE2 production. 15d-PGJ2-induced inhibition of type II collagen and SOX-9 expression was prevented by the addition of 10 µM BADGE (bisphenol A diglycidyl ether, PPAR-?
Negative_regulation (inhibition) of Gene_expression (expression) of SOX-9
6) Confidence 0.07 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693859 Disease Relevance 0 Pain Relevance 0.05
activation is associated with dedifferentiation and/or COX-2 expression and PGE2 production. 15d-PGJ2-induced inhibition of type II collagen and SOX-9 expression was prevented by the addition of 10 µM BADGE (bisphenol A diglycidyl ether, PPAR-?
Negative_regulation (prevented) of Gene_expression (expression) of SOX-9
7) Confidence 0.07 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693859 Disease Relevance 0 Pain Relevance 0.05

General Comments

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