INT184223

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 16
Disease Relevance 1.07
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS4) extracellular space (ADAMTS4) extracellular region (ADAMTS4)
proteinaceous extracellular matrix (ADAMTS4)
Anatomy Link Frequency
tendon cells 6
ADAMTS4 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 133 100.00 Very High Very High Very High
cytokine 151 98.70 Very High Very High Very High
agonist 30 93.84 High High
Mechanotransduction 11 85.60 High High
Pain 159 82.64 Quite High
rheumatoid arthritis 5 64.72 Quite High
antagonist 25 5.00 Very Low Very Low Very Low
backache 20 5.00 Very Low Very Low Very Low
Chronic low back pain 10 5.00 Very Low Very Low Very Low
Osteoarthritis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 35 99.18 Very High Very High Very High
Necrosis 21 95.16 Very High Very High Very High
Cancer 21 94.80 High High
Volume Depletion And Dehydration 5 94.44 High High
Tendinopathy 110 83.16 Quite High
Rheumatoid Arthritis 5 64.72 Quite High
Disease 15 61.12 Quite High
Intervertebral Disk Displacement 10 18.44 Low Low
Rupture 44 5.00 Very Low Very Low Very Low
Low Back Pain 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of ADAMTS-4 expression thus shows a degree of specificity within the TGF-?
Positive_regulation (activation) of Gene_expression (expression) of ADAMTS-4
1) Confidence 0.43 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.10
None of these BMP stimulated ADAMTS-4 mRNA expression, compared with 10- to 30-fold stimulation by TGF-?
Positive_regulation (stimulated) of Gene_expression (expression) of ADAMTS-4 mRNA
2) Confidence 0.43 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.11 Pain Relevance 0.03
on ADAMTS-4 mRNA expression, measured after 16 h (Tzusaki et al., 2003): our work indicates that the optimum stimulation by IL-1?
Positive_regulation (by) of Gene_expression (expression) of ADAMTS-4 mRNA
3) Confidence 0.31 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
Expression of ADAMTS-4 protein in tendon cells
Positive_regulation (tendon cells) of Gene_expression (Expression) of ADAMTS-4 in tendon cells
4) Confidence 0.31 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
on ADAMTS-4 mRNA expression, measured after 16 h (Tzusaki et al., 2003): our work indicates that the optimum stimulation by IL-1?
Positive_regulation (on) of Gene_expression (expression) of ADAMTS-4 mRNA
5) Confidence 0.31 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
The greatest stimulation of ADAMTS-4 mRNA expression by an individual growth factor or cytokine was induced by TGF-?
Positive_regulation (stimulation) of Gene_expression (expression) of ADAMTS-4 mRNA associated with cytokine
6) Confidence 0.29 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.19 Pain Relevance 0.09
We found that placing tendon cells in a three-dimensional collagen gel (a version of the fibroblast-populated collagen lattice: Ehrlich and Rittenberg, 2000; Grinnell, 2003) increased the expression of ADAMTS-4 mRNA relative to the monolayer and decreased that of ADAMTS-1 and ADAMTS-5 (Table 1).
Positive_regulation (increased) of Gene_expression (expression) of ADAMTS-4 mRNA in tendon cells
7) Confidence 0.29 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.12
induced the largest stimulation of ADAMTS-4 mRNA expression by any individual growth factor, and co-addition of TGF-?
Positive_regulation (induced) of Gene_expression (expression) of ADAMTS-4 mRNA
8) Confidence 0.29 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
Growth factors and cytokines, added to the cells after 48 h adaptation to serum-free medium, stimulated the expression of ADAMTS-4 mRNA, with different characteristic time-course and magnitude (Figs. 3 and 4).
Positive_regulation (stimulated) of Gene_expression (expression) of ADAMTS-4 mRNA associated with cytokine
9) Confidence 0.29 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.14 Pain Relevance 0.07
induced the largest stimulation of ADAMTS-4 mRNA expression by any individual growth factor, and co-addition of TGF-?
Positive_regulation (stimulation) of Gene_expression (expression) of ADAMTS-4 mRNA
10) Confidence 0.29 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0 Pain Relevance 0.03
ADAMTS-4 mRNA was expressed at higher levels by tendon cells in collagen gels than in monolayer cultures.
Positive_regulation (levels) of Gene_expression (expressed) of ADAMTS-4 mRNA in tendon cells
11) Confidence 0.29 Published 2008 Journal Matrix Biol Section Abstract Doc Link PMC2443387 Disease Relevance 0.16 Pain Relevance 0.23
Having established a basis for a functional excess of IL-1 in degenerate IVDs, we then investigated the role of IL-1 in the processes that characterize disc degeneration, namely, decreased matrix synthesis and increased production of MMPs and ADAMTS-4 [3-6].
Positive_regulation (increased) of Gene_expression (production) of ADAMTS-4 associated with intervertebral disk degeneration and metalloproteinase
12) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.23 Pain Relevance 0.08
We have previously shown an increase in ADAMTS-4 production by the cells of degenerate discs, especially in the NP [6], which, interestingly, were the same discs shown in this study to produce high levels of IL-1 agonists.


Positive_regulation (increase) of Gene_expression (production) of ADAMTS-4 associated with agonist
13) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.09 Pain Relevance 0.05
However, such treatment did result in an increase in the gene expression of the aggrecanase ADAMTS-4 in cells derived from degenerate NP.
Positive_regulation (result) of Gene_expression (expression) of ADAMTS-4
14) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.08 Pain Relevance 0.03
However, such treatment did result in an increase in the gene expression of the aggrecanase ADAMTS-4 in cells derived from degenerate NP.
Positive_regulation (increase) of Gene_expression (expression) of ADAMTS-4
15) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.08 Pain Relevance 0.03
Aggrecanase (ADAMTS-4 and -5) gene expression was increased in cells derived from the NP of degenerate discs.
Positive_regulation (increased) of Gene_expression (expression) of ADAMTS-4
16) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0

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