INT184241

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.89
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
spleen 2
T cell 2
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 160 100.00 Very High Very High Very High
rheumatoid arthritis 99 100.00 Very High Very High Very High
anesthesia 8 98.70 Very High Very High Very High
Inflammation 76 98.08 Very High Very High Very High
Arthritis 47 52.36 Quite High
chemokine 21 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 99 100.00 Very High Very High Very High
Stress 32 99.36 Very High Very High Very High
INFLAMMATION 53 98.08 Very High Very High Very High
Sprains And Strains 36 94.68 High High
Pneumonia 39 94.40 High High
Arthritis 46 93.04 High High
Hypersensitivity 6 91.52 High High
Conjunctivitis 50 81.20 Quite High
Dermatitis 27 81.08 Quite High
Disease 58 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, IL-2 and IL-4 secretion (spleen>>CLN) and IL-5 expression (spleen?
Regulation (spleen) of Localization (secretion) of IL-4 in spleen
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.53 Pain Relevance 0.06
and predominance of IL-4 and IL-13, in the earliest clinically apparent RA lesions was unexpected.
Regulation (unexpected) of Localization (predominance) of IL-4 associated with rheumatoid arthritis
2) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 1.74 Pain Relevance 0.78
In vitro studies on primary cultures of purified human CD4+ T cells showed evidence that oxidative stress could be induced which in turn modulated T cell polarization toward Th2 cytokine producing cells, including IL-4, IL-5, and IL-13 [38].
Regulation (modulated) of Localization (polarization) of IL-4 in T cell associated with stress and cytokine
3) Confidence 0.13 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994734 Disease Relevance 1.44 Pain Relevance 0.42
Surgery also contributes to the deviation of the immune response toward a Th2 and patients undergoing surgery and anesthesia have shown to present with down-regulated IL-2 secretion and up-regulated IL-10 and IL-4 secretion during the postoperative period.[34] However, in our study these confounding factors did not play much role as all patients underwent surgical procedures of almost similar duration, same type of anesthesia and single team of surgeons.
Regulation (regulated) of Localization (secretion) of IL-4 associated with anesthesia and cytokine
4) Confidence 0.07 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.17 Pain Relevance 0.32

General Comments

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