INT184257

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.32
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp8) extracellular space (Mmp8) extracellular region (Mmp8)
proteinaceous extracellular matrix (Mmp8)
Anatomy Link Frequency
lung 4
joint 2
livers 2
mononuclear cells 2
Mmp8 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 335 100.00 Very High Very High Very High
Inflammation 115 95.04 Very High Very High Very High
fibrosis 10 94.48 High High
rheumatoid arthritis 65 83.04 Quite High
alcohol 4 81.76 Quite High
Inflammatory mediators 1 66.20 Quite High
cytokine 43 53.48 Quite High
methotrexate 10 47.36 Quite Low
Inflammatory response 11 46.52 Quite Low
adenocard 1 30.80 Quite Low
Disease Link Frequency Relevance Heat
Bronchiolitis Obliterans 2 99.84 Very High Very High Very High
Lung Injury 128 99.16 Very High Very High Very High
Pulmonary Disease 10 98.44 Very High Very High Very High
Hyperoxia 2 97.80 Very High Very High Very High
Edema 2 96.84 Very High Very High Very High
Premature Birth 40 96.20 Very High Very High Very High
Cirrhosis 25 95.36 Very High Very High Very High
Cystic Fibrosis 2 94.48 High High
INFLAMMATION 128 93.96 High High
Bronchiectasis 2 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP8 expression was also increased following ventilation but it was restricted to certain cell types, presumably mononuclear cells, and localized primarily in the cell membrane (Figure 9, A and B).
Positive_regulation (increased) of Gene_expression (expression) of MMP8 in mononuclear cells
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.20 Pain Relevance 0.03
The effect of increased MMP8 expression in our model is detailed in Figure 12.
Positive_regulation (increased) of Gene_expression (expression) of MMP8
2) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 1.00 Pain Relevance 0.04
The assessment of MMP8 protein expression—a marker of neutrophil infiltration—was increased in whole livers of rats injected intravenously with mitochondrial DAMPs whereas control rats showed no evidence of hepatic inflammation.
Positive_regulation (increased) of Gene_expression (expression) of MMP8 in livers associated with cirrhosis and inflammation
3) Confidence 0.22 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.01 Pain Relevance 0.34
Taghavi and coworkers have described increased MMP-9 and MMP-8 levels in bronchiolitis obliterans from lung transplant patients [28].
Positive_regulation (increased) of Gene_expression (levels) of MMP-8 in lung associated with bronchiolitis obliterans and metalloproteinase
4) Confidence 0.14 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.45 Pain Relevance 0.95
Segura-Valdez et al. have found increased levels of MMP-8 and MMP-9 in Mini-BAL and lung biopsies of COPD patients [25].
Positive_regulation (increased) of Gene_expression (levels) of MMP-8 in lung associated with pulmonary disease and metalloproteinase
5) Confidence 0.13 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.21 Pain Relevance 0.97
It is possible that in the rheumatoid joint, where expression of MMP-8 and MMP-9 is increased [24], sRAGE levels are regulated by matrix metalloproteinases in a similar manner.
Positive_regulation (increased) of Gene_expression (expression) of MMP-8 in joint associated with metalloproteinase
6) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.78 Pain Relevance 0.37
In particular, an elevated MMP-8 level of >23?
Positive_regulation (elevated) of Gene_expression (level) of MMP-8
7) Confidence 0.09 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.68 Pain Relevance 0.04

General Comments

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