INT184262

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.49
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGER, HMGB1) extracellular region (AGER, HMGB1) cytoplasm (AGER, HMGB1)
nucleoplasm (HMGB1) nucleolus (HMGB1) nucleus (HMGB1)
AGER (Homo sapiens)
HMGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 99.56 Very High Very High Very High
Inflammation 125 98.60 Very High Very High Very High
rheumatoid arthritis 325 96.32 Very High Very High Very High
Osteoarthritis 10 90.92 High High
Arthritis 20 90.40 High High
methotrexate 50 89.48 High High
imagery 5 8.80 Low Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 135 98.60 Very High Very High Very High
Rheumatoid Arthritis 325 96.32 Very High Very High Very High
Osteoarthritis 10 90.92 High High
Arthritis 25 90.40 High High
Experimental Arthritis 5 85.44 High High
Disease 120 81.68 Quite High
Pathologic Processes 5 72.88 Quite High
Animal Disease Models 5 70.92 Quite High
Arthropathy 35 5.00 Very Low Very Low Very Low
Necrosis 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon co-incubation of these two proteins, however, HMGB1 binding to sRAGE did not affect the detection of the latter, indicating that lower sRAGE levels measured in RA patients are not due to neutralization by HMGB1.
sRAGE Binding (binding) of HMGB1 associated with rheumatoid arthritis
1) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.13 Pain Relevance 0.60
This prompted us to test whether HMGB1 binding to sRAGE influenced the detection of the latter in our experimental settings.
sRAGE Spec (whether) Binding (binding) of HMGB1
2) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.56 Pain Relevance 0.23
One of the high-affinity binding ligands for RAGE is HMGB1.
RAGE Binding (ligands) of HMGB1
3) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.66 Pain Relevance 0.31
One of the high-affinity ligands for RAGE/sRAGE is HMGB1, a potent cytokine playing an important role in the pathogenesis of chronic inflammation.
RAGE Binding (ligands) of HMGB1 associated with inflammation and cytokine
4) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.07 Pain Relevance 0.51
One of the high-affinity ligands for RAGE/sRAGE is HMGB1, a potent cytokine playing an important role in the pathogenesis of chronic inflammation.
sRAGE Binding (ligands) of HMGB1 associated with inflammation and cytokine
5) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.07 Pain Relevance 0.51

General Comments

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