INT184269

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 51
Total Number 55
Disease Relevance 42.96
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HMGB1) extracellular space (HMGB1) extracellular region (HMGB1)
nucleolus (HMGB1) nucleus (HMGB1) DNA binding (HMGB1)
Anatomy Link Frequency
neutrophils 2
internal 1
nucleus 1
HMGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 211 100.00 Very High Very High Very High
Arthritis 38 100.00 Very High Very High Very High
Glutamate 3 100.00 Very High Very High Very High
Inflammation 911 99.92 Very High Very High Very High
rheumatoid arthritis 160 98.56 Very High Very High Very High
cytokine 371 98.00 Very High Very High Very High
Inflammatory response 164 97.48 Very High Very High Very High
methotrexate 20 93.24 High High
anesthesia 30 87.92 High High
epidural 2 87.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1156 100.00 Very High Very High Very High
Cancer 827 100.00 Very High Very High Very High
Pancreatitis 57 100.00 Very High Very High Very High
Arthritis 25 100.00 Very High Very High Very High
Infection 1053 99.92 Very High Very High Very High
Sepsis 2116 99.84 Very High Very High Very High
Communicable Diseases 28 99.74 Very High Very High Very High
Critical Illness 84 99.72 Very High Very High Very High
Osteomyelitis 36 98.88 Very High Very High Very High
General Immunology 26 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of HMGB1, LBP and PCT related to the severity of infection
Gene_expression (Levels) of HMGB1 associated with infection
1) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 1.64 Pain Relevance 0
Levels of HMGB1, LBP and PCT in survivors and in fatal cases
Gene_expression (Levels) of HMGB1
2) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 1.46 Pain Relevance 0.04
Levels of HMGB1, PCT, LBP and IL-6 were previously measured in a control group consisting of 32 healthy hospital workers [14].


Gene_expression (Levels) of HMGB1
3) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.05 Pain Relevance 0
As mentioned earlier, levels of HMGB1 were much lower than levels reported in studies using blotting techniques.
Gene_expression (levels) of HMGB1
4) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.37 Pain Relevance 0.03
Levels of HMGB1, LBP and PCT in nonbacteraemic patients and in bacteraemic patients
Gene_expression (Levels) of HMGB1
5) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 1.07 Pain Relevance 0.05
In the present study the HMGB1 levels were comparable with the latter three aforementioned studies using ELISA for HMGB1 measurements [14,18,19].
Gene_expression (levels) of HMGB1
6) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.70 Pain Relevance 0
The HMGB1, LBP and PCT levels were significantly higher among patients with bacteraemia compared with the nonbacteraemic patients (P < 0.05) (Table 5).


Gene_expression (levels) of HMGB1
7) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.97 Pain Relevance 0.05
HMGB1 expression does not influence sRAGE detection by ELISA
Gene_expression (expression) of HMGB1
8) Confidence 0.63 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.72 Pain Relevance 0.34
The aim of the present study was to investigate levels of HMGB1, LBP and PCT in a well-characterised sepsis cohort.
Spec (investigate) Gene_expression (levels) of HMGB1 associated with sepsis
9) Confidence 0.60 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.78 Pain Relevance 0.09
Levels of HMGB1, LBP and PCT were higher in the severe sepsis group compared with the sepsis group (P < 0.01).
Gene_expression (Levels) of HMGB1 associated with sepsis
10) Confidence 0.60 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.91 Pain Relevance 0.08
Levels of HMGB1, LBP and PCT were higher in infected patients compared with a healthy control group (P < 0.0001).
Gene_expression (Levels) of HMGB1
11) Confidence 0.60 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.97 Pain Relevance 0.10
Levels of all studied inflammatory markers (HMGB1, LBP, PCT, IL-6) and infection markers (C-reactive protein, white blood cell count, neutrophils) were elevated among bacteraemic patients.
Gene_expression (Levels) of HMGB1 in neutrophils associated with inflammatory marker and infection
12) Confidence 0.60 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.75 Pain Relevance 0.09
Levels of all studied markers (HMGB1, LBP, PCT, IL-6, C-reactive protein, white blood cell count and neutrophils) were measured with commercially available laboratory techniques.


Gene_expression (Levels) of HMGB1 in neutrophils
13) Confidence 0.60 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.98 Pain Relevance 0.10
The present study purpose was to examine levels of HMGB1, LBP and PCT in patients with sepsis of different severity, in bacteraemic patients and in relation to the outcome of the patients.
Spec (examine) Gene_expression (levels) of HMGB1 associated with sepsis
14) Confidence 0.60 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.57 Pain Relevance 0.13
Levels of HMGB1, PCT and LBP were higher in infected patients compared with those in healthy controls, and levels were higher in severe sepsis patients compared with those in sepsis patients.
Gene_expression (Levels) of HMGB1 associated with sepsis
15) Confidence 0.60 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.71 Pain Relevance 0.08
All the laboratory analyses were carried out at the Children Clinical University Hospital (Latvia), except for HMGB 1 which was analyzed in the laboratory of Clinical Immunology and Immunogenetic, Riga Stradins University.


Gene_expression (analyzed) of HMGB associated with general immunology
16) Confidence 0.58 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 0.32 Pain Relevance 0.09
HMGB1 is a potent trigger of arthritis and its expression is increased in synovial tissue of RA patients as well as in experimental arthritis [12,17].
Gene_expression (expression) of HMGB1 associated with rheumatoid arthritis, experimental arthritis and arthritis
17) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.17 Pain Relevance 0.57
It is still unknown whether the currently used assays detect biologically active HMGB1.
Spec (whether) Gene_expression (detect) of HMGB1
18) Confidence 0.52 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.46 Pain Relevance 0.07
EGR1 and HMGB1 levels gradually decreased from the intraoperative values to baseline at POD 14.
Gene_expression (levels) of HMGB1
19) Confidence 0.50 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.17 Pain Relevance 0.04
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Gene_expression (levels) of HMGB1
20) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.49

General Comments

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