INT184271

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.17
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HMGB1) extracellular space (HMGB1) extracellular region (HMGB1)
nucleolus (HMGB1) nucleus (HMGB1) DNA binding (HMGB1)
HMGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 14 100.00 Very High Very High Very High
Inflammation 225 99.92 Very High Very High Very High
Glutamate 1 99.56 Very High Very High Very High
rheumatoid arthritis 133 99.08 Very High Very High Very High
cytokine 49 98.40 Very High Very High Very High
methotrexate 20 93.24 High High
Osteoarthritis 10 84.48 Quite High
Inflammatory marker 15 74.40 Quite High
imagery 10 12.56 Low Low
Abeta 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 13 100.00 Very High Very High Very High
INFLAMMATION 250 99.92 Very High Very High Very High
Critical Illness 6 99.72 Very High Very High Very High
Communicable Diseases 2 99.28 Very High Very High Very High
Rheumatoid Arthritis 133 99.08 Very High Very High Very High
Sepsis 150 98.56 Very High Very High Very High
Experimental Arthritis 2 98.04 Very High Very High Very High
Disease 82 96.84 Very High Very High Very High
Gastrointestinal Stromal Tumor 5 95.12 Very High Very High Very High
Cancer 206 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HMGB1 expression does not influence sRAGE detection by ELISA
Neg (not) Positive_regulation (influence) of Gene_expression (expression) of HMGB1
1) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.72 Pain Relevance 0.35
HMGB1 is a potent trigger of arthritis and its expression is increased in synovial tissue of RA patients as well as in experimental arthritis [12,17].
Positive_regulation (increased) of Gene_expression (expression) of HMGB1 associated with rheumatoid arthritis, experimental arthritis and arthritis
2) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.18 Pain Relevance 0.57
Similar findings were reported by Hatada et al. [11] who detected moderately elevated HMGB1 levels in patients with infectious diseases and highest HMGB1 levels in patients who died.
Positive_regulation (elevated) of Gene_expression (levels) of HMGB1 associated with communicable diseases
3) Confidence 0.28 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 0.94 Pain Relevance 0.12
In 1999, Wang et al [24] found increased levels of HMGB1 in 25 critically ill patients with sepsis, and significantly higher levels in those that succumbed to the disease.
Positive_regulation (increased) of Gene_expression (levels) of HMGB1 associated with critical illness, disease and sepsis
4) Confidence 0.28 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 0.80 Pain Relevance 0.13
HMGB1 signaling through TLR2 and TLR4 also results in expression of NF?
Positive_regulation (through) of Gene_expression (signaling) of HMGB1
5) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.74 Pain Relevance 0.21
Overview of HMGB1 and the HMG Protein Family
Positive_regulation (Overview) of Gene_expression (Overview) of HMGB1
6) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.12 Pain Relevance 0.06
HMGB1 has also been detected in the cytosol, depending on the cell type, where it has a major positive role in regulating autophagy [63].
Positive_regulation (detected) of Gene_expression (detected) of HMGB1
7) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.15 Pain Relevance 0.05
Among the 15 proteins differently expressed according to the mutation status, over-expression of 5 proteins (annexin V, high mobility group protein 1, C13orf2, glutamate dehydrogenase 1, and fibrinogen beta chain) and decreased expression of RoXaN correlated with a higher tumor grade.
Positive_regulation (over) of Gene_expression (expression) of high mobility group protein 1 associated with glutamate and cancer
8) Confidence 0.16 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.50 Pain Relevance 0.05

General Comments

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