INT184272

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 8.78
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HMGB1) extracellular space (HMGB1) extracellular region (HMGB1)
nucleolus (HMGB1) nucleus (HMGB1) DNA binding (HMGB1)
Anatomy Link Frequency
leukocytes 2
neuronal 1
tail 1
nucleus 1
HMGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 526 99.76 Very High Very High Very High
cytokine 124 99.68 Very High Very High Very High
rheumatoid arthritis 335 98.78 Very High Very High Very High
Pain 8 96.44 Very High Very High Very High
diabetic neuropathy 7 92.20 High High
Osteoarthritis 24 90.92 High High
Arthritis 36 85.44 High High
Inflammatory marker 19 83.76 Quite High
Inflammatory response 30 70.72 Quite High
methotrexate 50 69.52 Quite High
Disease Link Frequency Relevance Heat
Leukemia 34 100.00 Very High Very High Very High
INFLAMMATION 570 99.76 Very High Very High Very High
Breast Cancer 22 99.40 Very High Very High Very High
Rheumatoid Arthritis 335 98.78 Very High Very High Very High
Pain 7 96.44 Very High Very High Very High
Diabetes Mellitus 90 95.48 Very High Very High Very High
Alzheimer's Dementia 19 95.04 Very High Very High Very High
Cancer 285 93.84 High High
Diabetic Neuropathy 7 92.20 High High
Osteoarthritis 24 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diagnostic test abilities of HMGB1, LBP and PCT in diagnosing bacteraemia
HMGB1 Binding (abilities) of
1) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.74 Pain Relevance 0.04
Receiver┬ľoperator characteristic (ROC) curves and the area under the curve (AUC) were determined for HMGB1, LBP and PCT.
HMGB1 Spec (determined) Binding (determined) of
2) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0 Pain Relevance 0
2-integrin Mac-1 on leukocytes and the high mobility group box chromosomal protein 1 (HMGB1), all of which are associated with inflammation [2].
high mobility group box chromosomal protein 1 Binding (associated) of in leukocytes associated with inflammation
3) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.45 Pain Relevance 0.20
2-integrin Mac-1 on leukocytes and the high mobility group box chromosomal protein 1 (HMGB1), all of which are associated with inflammation [2].
HMGB1 Binding (associated) of in leukocytes associated with inflammation
4) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.40 Pain Relevance 0.20
This prompted us to test whether HMGB1 binding to sRAGE influenced the detection of the latter in our experimental settings.
HMGB1 Spec (whether) Binding (binding) of
5) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.56 Pain Relevance 0.23
Upon co-incubation of these two proteins, however, HMGB1 binding to sRAGE did not affect the detection of the latter, indicating that lower sRAGE levels measured in RA patients are not due to neutralization by HMGB1.
HMGB1 Binding (binding) of associated with rheumatoid arthritis
6) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.12 Pain Relevance 0.60
If it were the case, the decreased sRAGE levels found in our RA patient population would be explained by in vivo or ex vivo HMGB1 interaction.
HMGB1 Binding (interaction) of associated with rheumatoid arthritis
7) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.50 Pain Relevance 0.25
A peptide consisting of only residues 150┬ľ183 of HMGB1 (the end of the B-box and its linker to the acidic tail) exhibits RAGE binding and successfully competes with HMGB1 binding in vitro [95].
HMGB1 Binding (binding) of in tail
8) Confidence 0.25 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.21 Pain Relevance 0.17
Therefore any test of RAGE binding solely by HMGB1 will have to account for this, since contamination with even small amounts of LPS or CpG DNA will increase binding.
HMGB1 Binding (binding) of
9) Confidence 0.25 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.31 Pain Relevance 0.21
B activation by HMGB-1 binding, correlates with poor survival in breast cancer [11](L Zitvogel, France).
HMGB-1 Binding (binding) of associated with breast cancer
10) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.52 Pain Relevance 0.03
HMGB1 binding to RAGE is enhanced with CpG DNA.
HMGB1 Binding (binding) of
11) Confidence 0.19 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.31 Pain Relevance 0.21
The interaction between HMGB1 and RAGE in vitro promotes neurite outgrowth of cortical cells, suggesting a potential role of RAGE as a mediator in neuronal development [166].
HMGB1 Binding (interaction) of in neuronal
12) Confidence 0.19 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 1.10 Pain Relevance 0.26
The A-box and the oxidation state of these two cysteines play an important role in the ability of HMGB1 to bind substrates.
HMGB1 Binding (bind) of
13) Confidence 0.19 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0 Pain Relevance 0.03
Since HMGB1 translocates between the nucleus and cytosol, there is a possibility that it could bind to soluble RAGE in the cytosol and thereby play a role in regulating its activity.


HMGB1 Binding (bind) of in nucleus
14) Confidence 0.19 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.07 Pain Relevance 0.04
Addition of recombinant A-box antagonizes HMGB1's ability to bind other substrates [67,69].
HMGB1 Binding (bind) of
15) Confidence 0.19 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0 Pain Relevance 0.03
HBP1 is a high mobility group protein that interacts with and is transcriptionally regulated by Rb, functionally inhibits G1 to G2/S phase cell cycling in leukemia cell lines, and is associated with invasive breast cancer (Tevosian et al., 1997; Shih et al., 1998; Yao et al., 2005; Paulson et al., 2007).
high mobility group protein Binding (associated) of associated with leukemia and breast cancer
16) Confidence 0.05 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.77 Pain Relevance 0
HBP1 is a high mobility group protein that interacts with and is transcriptionally regulated by Rb, functionally inhibits G1 to G2/S phase cell cycling in leukemia cell lines, and is associated with invasive breast cancer (Tevosian et al., 1997; Shih et al., 1998; Yao et al., 2005; Paulson et al., 2007).
high mobility group protein Binding (interacts) of associated with leukemia and breast cancer
17) Confidence 0.05 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.73 Pain Relevance 0

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