INT184273

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.59
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGER) extracellular region (AGER) plasma membrane (AGER)
cytoplasm (AGER)
Anatomy Link Frequency
blood 2
endothelial cells 1
pericytes 1
AGER (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 325 100.00 Very High Very High Very High
Inflammation 125 97.48 Very High Very High Very High
Arthritis 20 88.76 High High
Osteoarthritis 10 87.36 High High
metalloproteinase 5 75.04 Quite High
cytokine 20 73.36 Quite High
Inflammatory response 10 61.32 Quite High
methotrexate 50 25.92 Quite Low
adenocard 5 9.36 Low Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 325 100.00 Very High Very High Very High
Disease 120 98.30 Very High Very High Very High
INFLAMMATION 135 97.48 Very High Very High Very High
Arthritis 25 88.76 High High
Osteoarthritis 10 87.36 High High
Experimental Arthritis 5 81.88 Quite High
Pathologic Processes 5 44.24 Quite Low
Arthropathy 35 43.92 Quite Low
Animal Disease Models 5 42.28 Quite Low
Alzheimer's Dementia 5 37.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In RA patients with erosive disease, we observed a positive correlation between the white blood cell count and synovial sRAGE levels, indicating that endothelial cells in the synovial blood secrete sRAGE extracellularly as a negative feedback mechanism to limit the inflammation.
Localization (secrete) of sRAGE in blood associated with inflammation, rheumatoid arthritis and disease
1) Confidence 0.60 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.64 Pain Relevance 0.28
In RA patients with erosive disease, we observed a positive correlation between the white blood cell count and synovial sRAGE levels, indicating that endothelial cells in the synovial blood secrete sRAGE extracellularly as a negative feedback mechanism to limit the inflammation.
Localization (secrete) of sRAGE in blood associated with inflammation, rheumatoid arthritis and disease
2) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.65 Pain Relevance 0.28
Upon co-incubation of these two proteins, however, HMGB1 binding to sRAGE did not affect the detection of the latter, indicating that lower sRAGE levels measured in RA patients are not due to neutralization by HMGB1.
Localization (neutralization) of sRAGE associated with rheumatoid arthritis
3) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.17 Pain Relevance 0.59
In addition, it has also been shown that pericytes and endothelial cells produce and release sRAGE extracellularly, suggesting the presence of a negative feedback mechanism in RAGE signalling [7].
Localization (release) of sRAGE in pericytes
4) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.57 Pain Relevance 0.26
In addition, it has also been shown that pericytes and endothelial cells produce and release sRAGE extracellularly, suggesting the presence of a negative feedback mechanism in RAGE signalling [7].
Localization (release) of sRAGE in endothelial cells
5) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.57 Pain Relevance 0.26

General Comments

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