INT184280

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 9.05
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGER) extracellular region (AGER) plasma membrane (AGER)
cytoplasm (AGER)
Anatomy Link Frequency
blood 2
arm 2
synovial fluid 1
AGER (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 262 100.00 Very High Very High Very High
methotrexate 40 99.08 Very High Very High Very High
Inflammation 128 95.04 Very High Very High Very High
Arthritis 18 93.32 High High
adenocard 4 89.28 High High
Osteoarthritis 8 87.36 High High
metalloproteinase 4 73.84 Quite High
cytokine 22 73.36 Quite High
Inflammatory marker 3 71.00 Quite High
Inflammatory response 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 262 100.00 Very High Very High Very High
Renal Disease 64 99.72 Very High Very High Very High
Arthritis 22 99.40 Very High Very High Very High
Diabetes Mellitus 217 99.02 Very High Very High Very High
Disease 154 98.20 Very High Very High Very High
Animal Disease Models 4 98.04 Very High Very High Very High
Pathologic Processes 4 96.04 Very High Very High Very High
INFLAMMATION 142 95.04 Very High Very High Very High
Hypersensitivity 32 94.80 High High
Alzheimer's Dementia 6 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with this concept, RA patients treated with methotrexate, one of the most efficient DMARDs, displayed increased sRAGE as compared with RA patients with no immunosuppressive treatment.
Positive_regulation (increased) of sRAGE associated with rheumatoid arthritis and methotrexate
1) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.01 Pain Relevance 0.62
LTA, TNF and the gene encoding for RAGE (AGER) are all located within the MHC complex on the short arm of chromosome 6.
Positive_regulation (located) of AGER in arm
2) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.26 Pain Relevance 0.19
LTA, TNF and the gene encoding for RAGE (AGER) are all located within the MHC complex on the short arm of chromosome 6.
Positive_regulation (located) of RAGE in arm
3) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.27 Pain Relevance 0.19
Type 1 diabetic patients with diabetic nephropathy had a higher frequency of the RAGE -374 A allele (31.2%) compared to those who maintained normoalbuminuria ?
Positive_regulation (frequency) of RAGE associated with diabetes mellitus and renal disease
4) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.03 Pain Relevance 0
Furthermore, highly increased serum and synovial fluid levels of EN-RAGE were found in arthritic patients in comparison with control subjects [19].
Positive_regulation (increased) of RAGE in synovial fluid associated with arthritis
5) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.01 Pain Relevance 0.48
Upon co-incubation of these two proteins, however, HMGB1 binding to sRAGE did not affect the detection of the latter, indicating that lower sRAGE levels measured in RA patients are not due to neutralization by HMGB1.
Neg (not) Positive_regulation (due) of sRAGE associated with rheumatoid arthritis
6) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.17 Pain Relevance 0.59
It therefore has the ability to prevent RAGE signalling acting as a decoy by binding ligands and preventing them from reaching cell surface RAGE. sRAGE has successfully been used in variety of animal disease models to antagonize RAGE-mediated pathologic processes [5,14-16].
Positive_regulation (reaching) of RAGE associated with pathologic processes and animal disease models
7) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.57 Pain Relevance 0.19
The binding of AGE to its receptor RAGE results in RAGE activation and the production of dysfunctioning proteins in tissues and in blood, and is strongly associated with a series of diseases from allergy and Alzheimers to rheuamtoid arthritis and urogenital disorders [34].
Positive_regulation (activation) of RAGE in blood associated with alzheimer's dementia, hypersensitivity, disease and arthritis
8) Confidence 0.05 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2685801 Disease Relevance 0.87 Pain Relevance 0.08
The binding of AGE to its receptor RAGE results in RAGE activation and the production of dysfunctioning proteins in tissues and in blood, and is strongly associated with a series of diseases from allergy and Alzheimers to rheuamtoid arthritis and urogenital disorders [34].
Positive_regulation (results) of RAGE in blood associated with alzheimer's dementia, hypersensitivity, disease and arthritis
9) Confidence 0.03 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2685801 Disease Relevance 0.87 Pain Relevance 0.08

General Comments

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