INT184281

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 23.06
Pain Relevance 7.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGER) extracellular region (AGER) plasma membrane (AGER)
cytoplasm (AGER)
Anatomy Link Frequency
joint 5
leukocyte 2
blood 1
arm 1
AGER (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 543 99.52 Very High Very High Very High
rheumatoid arthritis 1237 99.30 Very High Very High Very High
metalloproteinase 28 97.84 Very High Very High Very High
cytokine 92 97.64 Very High Very High Very High
Arthritis 78 97.24 Very High Very High Very High
methotrexate 190 94.60 High High
imagery 19 92.24 High High
Inflammatory response 48 90.00 High High
Osteoarthritis 38 77.20 Quite High
adenocard 19 44.08 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Complications 27 99.60 Very High Very High Very High
INFLAMMATION 598 99.52 Very High Very High Very High
Disease 564 99.52 Very High Very High Very High
Rheumatoid Arthritis 1237 99.30 Very High Very High Very High
Cancer 318 98.84 Very High Very High Very High
Arthropathy 133 98.76 Very High Very High Very High
Hypersensitivity 32 98.72 Very High Very High Very High
Alzheimer's Dementia 26 98.24 Very High Very High Very High
Diabetes Mellitus 285 97.60 Very High Very High Very High
Arthritis 97 97.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association patterns between diabetic complications and polymorphisms in LTA, TNF, AGER and HLA was complex and none of the studied polymorphism was associated with all diabetic complications in either type 1 or type 2 diabetic patients.
AGER Binding (associated) of associated with diabetes mellitus and diabetes complications
1) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 1.15 Pain Relevance 0
Taken together, we suggest that soluble RAGE may block the ligand–RAGE interaction on the cell surface by directly binding leukocyte ?
RAGE Binding (interaction) of in leukocyte
2) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.85 Pain Relevance 0.46
This soluble form of the receptor has the same ligand binding specificity and therefore competes with cell-bound RAGE for ligand binding, therefore functioning as a 'decoy' abrogating cellular activation, since the cell surface receptor remains unoccupied.
RAGE Binding (binding) of
3) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.36 Pain Relevance 0.18
Several candidate genes on the short arm of chromosome 6 including the HLA locus, TNF, LTA and AGER could be associated with late diabetic complications.
AGER Binding (associated) of in arm associated with diabetes complications
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2429972 Disease Relevance 0.42 Pain Relevance 0
One of the high-affinity binding ligands for RAGE is HMGB1.
RAGE Binding (binding) of
5) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.66 Pain Relevance 0.31
Taken together, we suggest that soluble RAGE may block the ligand–RAGE interaction on the cell surface by directly binding leukocyte ?
RAGE Binding (soluble) of in leukocyte
6) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.84 Pain Relevance 0.46
The haplotypic structure is complex and there is also a complex interaction between genes and gene products, as illustrated by the TNF gene polymorphism that can influence transcription of LTA [8], and receptor for advanced glycation end-products (RAGE), which after binding to its ligand can increase production of pro-inflammatory cytokines, among them TNF-?
RAGE Binding (binding) of associated with inflammation and cytokine
7) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 0.56 Pain Relevance 0.14
DMARD = disease-modifying anti-rheumatic drug; ELISA = enzyme-linked immunosorbent assay; EN-RAGE = extracellular newly identified RAGE-binding protein; HMGB1 = high-mobility group box chromosomal protein 1; IL = interleukin; NID = non-inflammatory joint disease; RA = rheumatoid arthritis; RAGE = receptor for advanced glycation end products; sRAGE = soluble receptor for advanced glycation end products.


RAGE Binding (binding) of in joint associated with inflammation, rheumatoid arthritis, arthropathy and disease
8) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.29 Pain Relevance 0.49
We investigated further the association between sRAGE levels with main characteristics of the disease.
sRAGE Binding (association) of associated with disease
9) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.78 Pain Relevance 0.32
Studies have shown that engagement of RAGE by a ligand results in a rapid and sustained cellular activation and gene transcription [1].
RAGE Binding (engagement) of
10) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.39 Pain Relevance 0.20
Alternatively, MMP-9 has been found to shed cell-bound RAGE into the culture medium in mice [23].
RAGE Binding (bound) of
11) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.72 Pain Relevance 0.33
Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control

The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily being expressed as a cell surface molecule and binding a variety of ligands.

RAGE Binding (binding) of associated with inflammation and rheumatoid arthritis
12) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1175032 Disease Relevance 1.18 Pain Relevance 0.51
In the inflammatory milieu, such as in the rheumatoid joint, other sRAGE ligands also exist.
sRAGE Binding (ligands) of in joint associated with inflammation
13) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.15 Pain Relevance 0.57
In the case of RA, there is a wide diversity of RAGE ligands present in the inflamed joints, as well as in the circulation, that could lead to the binding and consumption of sRAGE during the inflammatory process.
sRAGE Binding (binding) of in joints associated with inflammation and rheumatoid arthritis
14) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.04 Pain Relevance 0.49
Our aim was to analyse to what extent sRAGE is present in patients with chronic joint inflammation (RA) as compared with patients with non-inflammatory joint disease and with healthy subjects, and to assess whether there is an association between sRAGE levels and disease characteristics.
sRAGE Binding (association) of in joint associated with inflammation, rheumatoid arthritis, disease, arthropathy and arthritis
15) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175032 Disease Relevance 1.46 Pain Relevance 0.57
In humans, sRAGE is produced by alternative splicing of RAGE mRNA [6-8].
RAGE mRNA Binding (splicing) of
16) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.50 Pain Relevance 0.25
Our aim was to evaluate the levels of sRAGE in patients with RA and to assess whether there is an association between sRAGE levels and disease characteristics.
sRAGE Binding (association) of associated with rheumatoid arthritis and disease
17) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.01 Pain Relevance 0.37
The complex formation between these two proteins could possibly affect the measurement of sRAGE by ELISA.
sRAGE Binding (measurement) of
18) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.52 Pain Relevance 0.20
This prompted us to test whether HMGB1 binding to sRAGE influenced the detection of the latter in our experimental settings.
sRAGE Spec (whether) Binding (binding) of
19) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.56 Pain Relevance 0.23
DMARD = disease-modifying anti-rheumatic drug; ELISA = enzyme-linked immunosorbent assay; EN-RAGE = extracellular newly identified RAGE-binding protein; HMGB1 = high-mobility group box chromosomal protein 1; IL = interleukin; NID = non-inflammatory joint disease; RA = rheumatoid arthritis; RAGE = receptor for advanced glycation end products; sRAGE = soluble receptor for advanced glycation end products.


RAGE Binding (binding) of in joint associated with inflammation, rheumatoid arthritis, arthropathy and disease
20) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.31 Pain Relevance 0.49

General Comments

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