INT184284

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.95
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGER) extracellular region (AGER) plasma membrane (AGER)
cytoplasm (AGER)
Anatomy Link Frequency
joint 2
white blood cell 2
AGER (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 325 100.00 Very High Very High Very High
metalloproteinase 5 99.56 Very High Very High Very High
methotrexate 50 97.14 Very High Very High Very High
Inflammation 125 94.16 High High
imagery 5 85.68 High High
adenocard 5 33.44 Quite Low
Arthritis 20 15.92 Low Low
Osteoarthritis 10 14.80 Low Low
cytokine 20 8.40 Low Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 325 100.00 Very High Very High Very High
Disease 120 100.00 Very High Very High Very High
INFLAMMATION 135 94.16 High High
Arthritis 25 50.68 Quite High
Adhesions 5 28.88 Quite Low
Osteoarthritis 10 14.80 Low Low
Cancer 15 11.76 Low Low
Necrosis 15 11.20 Low Low
Experimental Arthritis 5 9.32 Low Low
Arthropathy 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of the treatment on sRAGE levels in RA patients
Regulation (effect) of Gene_expression (levels) of sRAGE associated with rheumatoid arthritis
1) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.13 Pain Relevance 0.48
Correlation between sRAGE levels and clinical features of RA
Regulation (Correlation) of Gene_expression (levels) of sRAGE associated with rheumatoid arthritis
2) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.73 Pain Relevance 0.32
In contrast, the synovial sRAGE levels in RA patients with erosive disease correlated significantly with synovial white blood cell counts (rs = 0.53, P < 0.04), whereas no association was found between synovial fluid sRAGE and synovial IL-6 levels in RA patients.


Regulation (correlated) of Gene_expression (levels) of sRAGE in white blood cell associated with rheumatoid arthritis and disease
3) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.19 Pain Relevance 0.48
It is possible that in the rheumatoid joint, where expression of MMP-8 and MMP-9 is increased [24], sRAGE levels are regulated by matrix metalloproteinases in a similar manner.
Regulation (regulated) of Gene_expression (levels) of sRAGE in joint associated with metalloproteinase
4) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.82 Pain Relevance 0.40
Since methotrexate is the most used DMARD in RA treatment and was predominant in our patient population, we decided to investigate whether this treatment had an effect of sRAGE levels in RA patients.
Spec (whether) Regulation (effect) of Gene_expression (levels) of sRAGE associated with rheumatoid arthritis and methotrexate
5) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.08 Pain Relevance 0.43

General Comments

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