INT184286

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2005
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.70
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGER) extracellular region (AGER) plasma membrane (AGER)
cytoplasm (AGER)
Anatomy Link Frequency
joint 1
AGER (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 455 100.00 Very High Very High Very High
metalloproteinase 7 99.56 Very High Very High Very High
Inflammation 175 98.28 Very High Very High Very High
methotrexate 70 97.14 Very High Very High Very High
Osteoarthritis 14 87.36 High High
Arthritis 28 81.88 Quite High
cytokine 28 77.72 Quite High
adenocard 7 65.24 Quite High
imagery 7 63.24 Quite High
Inflammatory response 14 52.64 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 455 100.00 Very High Very High Very High
INFLAMMATION 189 98.28 Very High Very High Very High
Disease 168 92.20 High High
Osteoarthritis 14 87.36 High High
Experimental Arthritis 7 81.88 Quite High
Arthritis 35 80.08 Quite High
Necrosis 21 76.32 Quite High
Cancer 21 75.96 Quite High
Adhesions 7 67.48 Quite High
Arthropathy 49 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proportion and production of the soluble form of the endogenous receptor may therefore influence the regulation of RAGE-mediated functions in various tissues and inflammatory conditions, including RA.
Regulation (regulation) of RAGE associated with inflammation and rheumatoid arthritis
1) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.76 Pain Relevance 0.32
Upon co-incubation of these two proteins, however, HMGB1 binding to sRAGE did not affect the detection of the latter, indicating that lower sRAGE levels measured in RA patients are not due to neutralization by HMGB1.
Neg (not) Regulation (due) of sRAGE associated with rheumatoid arthritis
2) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.17 Pain Relevance 0.59
Since methotrexate is the most used DMARD in RA treatment and was predominant in our patient population, we decided to investigate whether this treatment had an effect of sRAGE levels in RA patients.
Spec (whether) Regulation (effect) of sRAGE associated with rheumatoid arthritis and methotrexate
3) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.08 Pain Relevance 0.43
The effect of the treatment on sRAGE levels in RA patients
Regulation (effect) of sRAGE associated with rheumatoid arthritis
4) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.13 Pain Relevance 0.48
It is possible that in the rheumatoid joint, where expression of MMP-8 and MMP-9 is increased [24], sRAGE levels are regulated by matrix metalloproteinases in a similar manner.
Regulation (regulated) of sRAGE in joint associated with metalloproteinase
5) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.82 Pain Relevance 0.40
The proportion and production of the soluble form of the endogenous receptor may therefore influence the regulation of RAGE-mediated functions in various tissues and inflammatory conditions, including RA.
Regulation (regulation) of RAGE associated with inflammation and rheumatoid arthritis
6) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 1.22 Pain Relevance 0.58
The complex formation between these two proteins could possibly affect the measurement of sRAGE by ELISA.
Regulation (affect) of sRAGE
7) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175032 Disease Relevance 0.52 Pain Relevance 0.20

General Comments

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