INT1843

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Context Info
Confidence 0.69
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 2.16
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hrasls)
Anatomy Link Frequency
neuron 2
uterine 1
adrenal cortex 1
cortex 1
frontal cortex 1
Hrasls (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 25 99.98 Very High Very High Very High
local anesthetic 3 99.72 Very High Very High Very High
Neuropeptide 6 99.66 Very High Very High Very High
Kappa opioid receptor 1 99.62 Very High Very High Very High
Clonidine 7 98.66 Very High Very High Very High
antidepressant 98 98.32 Very High Very High Very High
carbamazepine 2 98.12 Very High Very High Very High
dexamethasone 8 97.60 Very High Very High Very High
Potency 5 96.52 Very High Very High Very High
agonist 10 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 15 99.92 Very High Very High Very High
Urological Neuroanatomy 16 99.56 Very High Very High Very High
Manic Depressive Disorder 3 96.40 Very High Very High Very High
Cv Unclassified Under Development 6 94.56 High High
Decapitation 3 92.96 High High
Diabetes Mellitus 90 92.52 High High
Cancer 9 86.16 High High
Depression 13 84.60 Quite High
Drug Induced Neurotoxicity 1 65.44 Quite High
Colon Cancer 8 58.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that clonidine (but not xylazine) stimulates prostaglandin synthesis possibly by activating phospholipase activity and releasing arachidonic acid from membrane phospholipids.
Positive_regulation (activating) of phospholipase associated with clonidine
1) Confidence 0.69 Published 1982 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6129303 Disease Relevance 0 Pain Relevance 0.56
Since the phospholipase C inhibitors, neomycin (1 mM) and 2-nitro-4-carboxyphenyl-N, N-diphenylcarbamate (NCDC, 10 microM), respectively, specifically abolished the potentiation, the potentiation by neuropeptide Y may depend on activation of phospholipase C.
Positive_regulation (activation) of phospholipase associated with neuropeptide
2) Confidence 0.44 Published 2007 Journal Vascul. Pharmacol. Section Abstract Doc Link 17169617 Disease Relevance 0 Pain Relevance 0.31
Stimulation and inhibition of pancreatic phospholipase A2 by local anesthetics as a result of their interaction with the substrate.
Positive_regulation (pancreatic) of pancreatic phospholipase associated with local anesthetic
3) Confidence 0.42 Published 1975 Journal Biochim. Biophys. Acta Section Title Doc Link 240410 Disease Relevance 0 Pain Relevance 0.23
When Nembutal was used as anesthetic, the phospholipase activation was earlier, within the first 30 s.
Positive_regulation (activation) of phospholipase
4) Confidence 0.37 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7119783 Disease Relevance 0.34 Pain Relevance 0.26
This increase is, at least in part, due to phospholipase A activation.
Positive_regulation (activation) of phospholipase
5) Confidence 0.37 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7119783 Disease Relevance 0.32 Pain Relevance 0.24
Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex.
Positive_regulation (upregulates) of phospholipase in frontal cortex associated with urological neuroanatomy and fluoxetine
6) Confidence 0.26 Published 2006 Journal Pharmacogenomics J. Section Title Doc Link 16636684 Disease Relevance 0.54 Pain Relevance 0.51
Finally, studies on the second messenger systems activated by the opioid peptides and the receptor agonists showed that these peptides act to increase labelling of inositol trisphosphate, and strongly suggest that, in the rat adrenal cortex, both mu and kappa opioid receptors are linked to the activation of phospholipase C.
Positive_regulation (activation) of phospholipase in adrenal cortex associated with kappa opioid receptor, agonist and opioid
7) Confidence 0.20 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7738474 Disease Relevance 0 Pain Relevance 0.80
In the presence of deoxycholate, it showed phospholipase activity which was activated by Ca2+ but not Sr2+.beta-Bungarotoxin and tityustoxin, a polypeptide that prolongs the opening of sodium channels, inhibited choline accumulation by synaptosomes purified from rat cortex.
Positive_regulation (activated) of phospholipase in cortex associated with sodium channel
8) Confidence 0.15 Published 1980 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7353009 Disease Relevance 0 Pain Relevance 0.08
DEX presumably acts on its receptors on the CRF neuron to inhibit the increase in intracellular calcium and thereby blocks activation of phospholipase A2 necessary for activation of the arachidonic acid cascade. alpha-MSH and LHRH may similarly act on their receptors on these cells to, in some manner, block the pathway.
Positive_regulation (activation) of phospholipase in neuron associated with dexamethasone
9) Confidence 0.10 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0 Pain Relevance 0.32
The DA D1 receptors show characteristic ability to stimulate adenylyl cyclase and generate inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol via the activation of phospholipase C [65,66].
Positive_regulation (activation) of phospholipase
10) Confidence 0.07 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.47 Pain Relevance 0.26
DEX presumably acts on its receptors on the CRF neuron to inhibit the increase in intracellular calcium and thereby blocks activation of phospholipase A2 necessary for activation of the arachidonic acid cascade. alpha-MSH and LHRH may similarly act on their receptors on these cells to, in some manner, block the pathway.
Positive_regulation (necessary) of phospholipase in neuron associated with dexamethasone
11) Confidence 0.07 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0 Pain Relevance 0.32
Tamoxifen and the raloxifene analog, LY117018, may prevent estrogen-independent as well as estrogen-dependent breast cancer by stimulating phospholipase activity and initiating arachidonic acid release.
Positive_regulation (stimulating) of phospholipase associated with breast cancer
12) Confidence 0.06 Published 2004 Journal BMC Cancer Section Abstract Doc Link PMC514706 Disease Relevance 0.36 Pain Relevance 0.05
Studies investigating the mechanism of lindane-induced inhibition of uterine contractility suggest that activation of phospholipase C and generation of reactive oxygen species are mechanistic links between inhibition of myometrial gap junctions and inhibition of uterine contractility [2,4].
Positive_regulation (activation) of phospholipase in uterine
13) Confidence 0.05 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC222921 Disease Relevance 0.07 Pain Relevance 0
The accumulation of inositol phosphates requires receptor-coupled stimulation of phospholipase C.
Positive_regulation (stimulation) of phospholipase
14) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2823756 Disease Relevance 0.06 Pain Relevance 0.49
Additionally, phosphatidylinositol is able to accumulate because, as explained above, there is no mechanism to stimulate the activity of phospholipase C which is required to break down the phospholipid.
Positive_regulation (stimulate) of phospholipase
15) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2823756 Disease Relevance 0 Pain Relevance 0.30
However, with sonicated radioactively-labelled phosphatidylcholine or phosphatidylethanolamine as substrate, stimulation of phospholipase activity was seen with all local anaesthetics up to 10(-2) M, the order of decreasing potency again being chlorpromazine, dibucaine, tetracaine, lidocaine, cocaine and procaine.
Positive_regulation (stimulation) of phospholipase associated with lidocaine, cocaine and potency
16) Confidence 0.02 Published 1976 Journal Biochim. Biophys. Acta Section Abstract Doc Link 952985 Disease Relevance 0 Pain Relevance 0.35

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