INT18430

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Context Info
Confidence 0.24
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 0.81
Pain Relevance 14.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Hps4) cytoplasmic membrane-bounded vesicle (Hps4) lysosome (Hps4)
cytoplasm (Hps4)
Anatomy Link Frequency
CSF 1
striatum 1
posterior pituitary 1
substantia nigra 1
hypothalamus 1
Hps4 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 110 100.00 Very High Very High Very High
Dynorphin 86 100.00 Very High Very High Very High
Opioid 63 99.72 Very High Very High Very High
Substantia nigra 8 99.68 Very High Very High Very High
Somatostatin 8 98.80 Very High Very High Very High
agonist 5 98.76 Very High Very High Very High
substance P 13 98.44 Very High Very High Very High
narcan 48 98.12 Very High Very High Very High
Spinal cord 25 97.76 Very High Very High Very High
opioid receptor 79 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 2 99.22 Very High Very High Very High
Ganglion Cysts 1 91.44 High High
Increased Venous Pressure Under Development 2 89.76 High High
Hypertrophy 1 83.68 Quite High
INFLAMMATION 4 75.04 Quite High
Pain 30 75.00 Quite High
Hyperalgesia 6 59.08 Quite High
Pressure And Volume Under Development 3 45.60 Quite Low
Targeted Disruption 6 13.24 Low Low
Nociception 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal cord explants with attached dorsal root ganglia (DRGs), from 14-day fetal mice were fixed at 1-3 weeks in vitro and incubated for leucine-enkephalin (LE) immunoreactivity by the peroxidase-anti-peroxidase (PAP) immunohistochemical method.
Positive_regulation (incubated) of LE in dorsal root ganglia associated with enkephalin and spinal cord
1) Confidence 0.24 Published 1981 Journal Peptides Section Abstract Doc Link 7267405 Disease Relevance 0.17 Pain Relevance 0.48
This modulatory effect of LE is completely blocked by addition of 10(-7) M naloxone, and seems to be catecholamine-receptor specific, since the positive chronotropic response to forskolin is unaltered in the presence of LE.
Positive_regulation (effect) of LE associated with catecholamine, narcan and enkephalin
2) Confidence 0.19 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6538941 Disease Relevance 0 Pain Relevance 0.85
Hydroxylation of LE was found to decrease receptor affinity to both mu and delta opioid receptor sites by a factor of about 20.
Positive_regulation (Hydroxylation) of LE associated with opioid receptor
3) Confidence 0.10 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8186271 Disease Relevance 0 Pain Relevance 0.39
In accordance with the experiment, no analgesic effect was observed in the acetic acid writhing assay of mice after s.c. administration (for peripheral effect) of LE or cellobiose-coupled LE (CcpLE) without peptidase inhibitors, whereas CcpLE as well as LE had analgesic activity by subcutaneous administration (s.c.) to mice pretreated with peptidase inhibitors, On the other hand, hot-plate assay (for central effect) did not indicate obvious analgesic effect after s.c. administration of CcpLE or EcpLE with pretreatment of peptidase inhibitors.
Positive_regulation (coupled) of CcpLE associated with analgesic
4) Confidence 0.09 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.53
In accordance with the experiment, no analgesic effect was observed in the acetic acid writhing assay of mice after s.c. administration (for peripheral effect) of LE or cellobiose-coupled LE (CcpLE) without peptidase inhibitors, whereas CcpLE as well as LE had analgesic activity by subcutaneous administration (s.c.) to mice pretreated with peptidase inhibitors, On the other hand, hot-plate assay (for central effect) did not indicate obvious analgesic effect after s.c. administration of CcpLE or EcpLE with pretreatment of peptidase inhibitors.
Positive_regulation (coupled) of LE associated with analgesic
5) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.53
SRIF and SP appear in the early fetal period before the establishment of the spinal synaptic transmission system, and their appearance precedes that of LE and NT, thus suggesting that SRIF and SP might have some important role in the development of the spinal cord.
Positive_regulation (precedes) of LE in spinal associated with somatostatin, enkephalin, spinal cord and substance p
6) Confidence 0.04 Published 1982 Journal J. Comp. Neurol. Section Abstract Doc Link 6181101 Disease Relevance 0.09 Pain Relevance 1.12
Recent studies have indicated that opioid peptide receptors are present on cardiac ventricular cells and that Leucine enkephalin (LE), a naturally occurring delta opioid peptide receptor agonist, leads to marked reductions in twitch amplitude and in the cytosolic Ca2+ transient (Ca(i)) of single adult rat ventricular myocytes.
Positive_regulation (occurring) of LE in myocytes associated with agonist, enkephalin and opioid
7) Confidence 0.03 Published 1993 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 8411192 Disease Relevance 0 Pain Relevance 0.77
Mild intermittent foot shock (0.2 mA, 20 min) causes a significant increase of dynorphin B and LE in the substantia nigra, but has no effect on ME-Arg-Gly-Leu concentrations.
Positive_regulation (increase) of LE in substantia nigra associated with dynorphin, substantia nigra, shock and enkephalin
8) Confidence 0.03 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860603 Disease Relevance 0.10 Pain Relevance 1.44
Two tyrosine specific, HPLC methods with either electrochemical (HPLC-ED) or fluorescence (HPLC-FL) detection are described for leucine-enkephalin (LE) in cerebrospinal fluid (CSF).
Positive_regulation (described) of LE in CSF associated with enkephalin
9) Confidence 0.02 Published 1999 Journal J Pharm Biomed Anal Section Abstract Doc Link 10698551 Disease Relevance 0 Pain Relevance 0.50
At 5 weeks, levels of ir-ME and ir-LE also were increased in the ipsilateral and contralateral dorsal horns, but not in the contralateral ventral horn.
Neg (not) Positive_regulation (increased) of LE in horn associated with enkephalin
10) Confidence 0.02 Published 1988 Journal Pain Section Abstract Doc Link 2906425 Disease Relevance 0.37 Pain Relevance 1.72
In the striatum, the levels of LE (33%) and DYN (115%) were elevated during chronic administration.
Positive_regulation (elevated) of LE in striatum associated with dynorphin and enkephalin
11) Confidence 0.02 Published 1985 Journal Peptides Section Abstract Doc Link 2866495 Disease Relevance 0 Pain Relevance 1.42
The same dose on chronic administration also decreased DYN, but increased the levels of ME and LE in the pituitary by 331 and 69%, respectively.
Positive_regulation (increased) of LE in pituitary associated with dynorphin and enkephalin
12) Confidence 0.02 Published 1985 Journal Peptides Section Abstract Doc Link 2866495 Disease Relevance 0 Pain Relevance 1.46
In the hypothalamus, chronic administration of NE + EE2 increased the level of ME (155%) and LE (87%) as well as of DYN (97%).
Positive_regulation (increased) of LE in hypothalamus associated with dynorphin and enkephalin
13) Confidence 0.02 Published 1985 Journal Peptides Section Abstract Doc Link 2866495 Disease Relevance 0 Pain Relevance 1.48
Likewise, in the posterior pituitary, osmotic stimulus (e.g., 2% NaCl as drinking fluid) causes marked depletion in dynorphin and LE but has no effect on ME levels suggesting that in the posterior pituitary LE is derived primarily from dynorphin.
Positive_regulation (derived) of LE in posterior pituitary associated with dynorphin and enkephalin
14) Confidence 0.02 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860603 Disease Relevance 0.08 Pain Relevance 1.33
Immunoreactive LE, which is normally not found in CSF, increased rapidly in content following Dyn A-(1-8) infusion, an observation suggesting that the larger peptide is converted to LE.
Positive_regulation (increased) of LE associated with dynorphin and enkephalin
15) Confidence 0.01 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1973455 Disease Relevance 0 Pain Relevance 0.80

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