INT184301

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 11.22
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bglap) cytoplasm (Bglap)
Anatomy Link Frequency
osteoblast 2
sympathetic 2
Bglap (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 38 99.32 Very High Very High Very High
rheumatoid arthritis 25 99.28 Very High Very High Very High
cytokine 28 97.88 Very High Very High Very High
imagery 26 96.44 Very High Very High Very High
Chronic pancreatitis 108 96.32 Very High Very High Very High
fibrosis 6 62.76 Quite High
corticosteroid 1 60.36 Quite High
Inflammation 15 57.24 Quite High
tolerance 15 34.96 Quite Low
Pain 8 12.88 Low Low
Disease Link Frequency Relevance Heat
Obesity 145 99.80 Very High Very High Very High
Impaired Glucose Tolerance 15 99.52 Very High Very High Very High
Hyperinsulinism 65 99.44 Very High Very High Very High
Adenocarcinoma 186 99.32 Very High Very High Very High
Arthritis 65 99.32 Very High Very High Very High
Rheumatoid Arthritis 25 99.28 Very High Very High Very High
Multiple Myeloma 12 99.28 Very High Very High Very High
Malignant Neoplastic Disease 18 99.12 Very High Very High Very High
Cancer 92 98.64 Very High Very High Very High
Osteoporosis 91 98.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, there was a decrease of BGLAP serum levels in PDAC patients compared to healthy controls.
Negative_regulation (decrease) of BGLAP associated with adenocarcinoma
1) Confidence 0.56 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.23 Pain Relevance 0.26
was able to moderately but consistently reduce BGLAP mRNA and protein levels in the four cultured pancreatic cancer cell lines (figure 6A &6B).
Negative_regulation (reduce) of BGLAP associated with pancreatic cancer
2) Confidence 0.56 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.96 Pain Relevance 0.09
This analysis revealed a significant reduction in BGLAP serum levels in PDAC patients (figure 4; p < 0.05).
Negative_regulation (reduction) of BGLAP associated with adenocarcinoma
3) Confidence 0.49 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.26 Pain Relevance 0.31
Indeed, to a substantial extent, leptin's inhibition of insulin secretion relies on a three-step cascade, including (1) leptin's up-regulation of sympathetic tone, (2) sympathetic enhancement of Esp expression in osteoblasts, and (3) decrease in osteocalcin bioactivity.
Negative_regulation (decrease) of osteocalcin in sympathetic
4) Confidence 0.48 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.39 Pain Relevance 0
Thus, serum BGLAP levels are reduced in patients with multiple myeloma with osteolytic bone lesions [11].
Negative_regulation (reduced) of BGLAP associated with multiple myeloma
5) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.86 Pain Relevance 0.05
Determination of the BGLAP protein levels was performed with an enzyme immunoassay (EIA) kit (Takara Bio Inc., Shiga, Japan).
Negative_regulation (Determination) of BGLAP
6) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.07 Pain Relevance 0.05
The maximum effects were observed in Aspc-1, where BGLAP mRNA and protein levels were reduced by -32.3 +/- 7.9% and -38.8 +/- 2% (p < 0.01), respectively.
Negative_regulation (reduced) of BGLAP
7) Confidence 0.41 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.75 Pain Relevance 0.09
In osteoblasts, sympathetic tone stimulates expression of Esp, a gene inhibiting the activity of osteocalcin, which is an insulin secretagogue.
Negative_regulation (inhibiting) of osteocalcin in sympathetic
8) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2606962 Disease Relevance 0.63 Pain Relevance 0
Accordingly, Esp inactivation doubles hyperinsulinemia and delays glucose intolerance in ob/ob mice, whereas Osteocalcin inactivation halves their hyperinsulinemia.
Negative_regulation (inactivation) of Osteocalcin associated with obesity, hyperinsulinism and impaired glucose tolerance
9) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2606962 Disease Relevance 0.65 Pain Relevance 0
Leptin affects osteoblast functions, raising the testable hypothesis that it could inhibit insulin secretion by decreasing osteocalcin activity (Ducy et al., 2000; Takeda et al., 2002).
Negative_regulation (decreasing) of osteocalcin in osteoblast associated with osteoporosis
10) Confidence 0.35 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.37 Pain Relevance 0
Finally, the Fsr system, a major positive and negative transcriptional regulator in OG1RF [22], affects expression of several virulence factor genes, including gelE, which encodes gelatinase [23], and contributes to infection in various animal models [15,24].
Negative_regulation (regulator) of OG1RF associated with infection
11) Confidence 0.26 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.63 Pain Relevance 0
In contrast to what Garnero and colleagues found in RA patients, we failed to demonstrate decreased serum levels of osteocalcin associated with arthritis.
Negative_regulation (decreased) of osteocalcin associated with rheumatoid arthritis and arthritis
12) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.37 Pain Relevance 0.37
When compared with OG1RF, transposon mutants [12] in the OG1RF equivalent of EF2045 (encoding the comGB homologue) and in the OG1RF equivalent of EF1986 (encoding the comGF homologue) showed similar levels of transformability by electroporation (data not shown), implying that the difference in electroporation efficiency observed between OG1RF and V583 is not related to this locus.
Negative_regulation (equivalent) of OG1RF
13) Confidence 0.22 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.07 Pain Relevance 0
By probing a microarray of the V583 genome and plasmids with OG1RF genomic DNA, we previously estimated that only 75% of V583 ORFs were also present in OG1RF [22].
Negative_regulation (present) of OG1RF
14) Confidence 0.19 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.18 Pain Relevance 0
In osteoblasts, sympathetic tone stimulates expression of Esp, a gene inhibiting the activity of osteocalcin, which is an insulin secretagogue.
Negative_regulation (inhibiting) of osteocalcin in osteoblasts
15) Confidence 0.12 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2606962 Disease Relevance 0.63 Pain Relevance 0
Moreover, significant decreases in serum osteocalcin and type 1 collagen C-telopeptide levels from baseline and relative to placebo were observed with all active treatments as early as 3 months and were sustained throughout the study.
Negative_regulation (decreases) of osteocalcin
16) Confidence 0.05 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643104 Disease Relevance 0.16 Pain Relevance 0

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