INT184303

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.66
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bglap) cytoplasm (Bglap)
Anatomy Link Frequency
osteoblast 2
sympathetic 1
osteoclasts 1
Bglap (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 76 95.52 Very High Very High Very High
Chronic pancreatitis 36 89.76 High High
cytokine 16 89.04 High High
imagery 15 68.96 Quite High
Pain 3 67.92 Quite High
Somatostatin 18 64.52 Quite High
dexamethasone 5 60.48 Quite High
tolerance 9 55.36 Quite High
Potency 3 55.16 Quite High
rheumatoid arthritis 50 55.08 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 118 100.00 Very High Very High Very High
Adenocarcinoma 62 99.60 Very High Very High Very High
Hypercalcemia 27 99.52 Very High Very High Very High
Disease 33 98.92 Very High Very High Very High
Hyperinsulinism 26 98.92 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

30 98.62 Very High Very High Very High
Bacterial Meningitis 6 98.48 Very High Very High Very High
Obesity 58 98.00 Very High Very High Very High
Cancer 51 95.56 Very High Very High Very High
Arthritis 130 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This might explain the elevated BGLAP serum levels in healthy controls despite similar amounts of BGLAP mRNA in bulk diseased pancreatic tissues.
Positive_regulation (elevated) of BGLAP
1) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.22 Pain Relevance 0.14
First, increasing osteocalcin bioactivity should worsen hyperinsulinemia in ob/ob mice.
Positive_regulation (increasing) of osteocalcin associated with obesity and hyperinsulinism
2) Confidence 0.57 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.65 Pain Relevance 0.06
It is interesting to note that this region contains: a putative adhesin protein gene (OG1RF_0039) at one end of the fragment; homologues of 14 Tn916-associated genes (Tn916_2 to Tn916_12, Tn916_18 and Tn916_19, with an average of 70% similarity); and a gene encoding a putative integrase (OG1RF_0088) at the other end - these three features are also present in Tn5386 in E. faecium D344R [46].
Positive_regulation (putative) of OG1
3) Confidence 0.49 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.13 Pain Relevance 0
The relevance of osteocalcin in the leptin-dependent sympathetic regulation of insulin secretion was also verified in vivo.
Positive_regulation (relevance) of osteocalcin in sympathetic
4) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.52 Pain Relevance 0.03
At day 45, serum levels of osteocalcin were increased in ovariectomized mice compared with sham-operated mice (Fig. 4a).
Positive_regulation (increased) of osteocalcin
5) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.17 Pain Relevance 0.34
When compared with OG1RF, transposon mutants [12] in the OG1RF equivalent of EF2045 (encoding the comGB homologue) and in the OG1RF equivalent of EF1986 (encoding the comGF homologue) showed similar levels of transformability by electroporation (data not shown), implying that the difference in electroporation efficiency observed between OG1RF and V583 is not related to this locus.
Positive_regulation (equivalent) of OG1RF
6) Confidence 0.26 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.07 Pain Relevance 0
Sanger sequencing was used for OG1RF whole gun sequencing and finishing.
Positive_regulation (used) of OG1RF
7) Confidence 0.26 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.18 Pain Relevance 0
Since we did not identify any remnants of the iol operon in V583, it would appear that at least two independent events at the same location differentiate OG1RF and V583, suggesting that it is a hot region for rearrangement.
Positive_regulation (differentiate) of OG1RF
8) Confidence 0.26 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.30 Pain Relevance 0
When compared with OG1RF, transposon mutants [12] in the OG1RF equivalent of EF2045 (encoding the comGB homologue) and in the OG1RF equivalent of EF1986 (encoding the comGF homologue) showed similar levels of transformability by electroporation (data not shown), implying that the difference in electroporation efficiency observed between OG1RF and V583 is not related to this locus.
Neg (not) Positive_regulation (related) of OG1RF
9) Confidence 0.26 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.10 Pain Relevance 0
When compared with OG1RF, transposon mutants [12] in the OG1RF equivalent of EF2045 (encoding the comGB homologue) and in the OG1RF equivalent of EF1986 (encoding the comGF homologue) showed similar levels of transformability by electroporation (data not shown), implying that the difference in electroporation efficiency observed between OG1RF and V583 is not related to this locus.
Positive_regulation (equivalent) of OG1RF
10) Confidence 0.22 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.08 Pain Relevance 0
Indeed, the finding that RatLaps, a serum marker of bone resorption, was unaltered whereas osteocalcin, a serum marker of bone formation, was increased in ovariectomized mice indicates that the period of OVX-induced increased activation of osteoclasts had already ended at this late time point.
Positive_regulation (increased) of osteocalcin in osteoclasts associated with hypercalcemia
11) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 0.56 Pain Relevance 0.09
This analysis revealed a significant increase in the mRNA ratio of BGLAP/Amy2A in PDAC (p < 0.0001) compared to normal pancreatic tissues.
Positive_regulation (increase) of BGLAP associated with adenocarcinoma
12) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.63 Pain Relevance 0.39
The present study shows the effect of osteoplant on PB-hMSCs in the early differentiation stages, as indicated by the activation of bone-related markers RUNX1, BGLAP, and SPP1.
Positive_regulation (activation) of BGLAP
13) Confidence 0.11 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.39 Pain Relevance 0.06
The osteoplant causes induction of osteoblast transcriptional factors such as osterix (RUNX2), and of bone-related genes such as osteopontin (SPP1) and osteocalcin (BGLAP).
Positive_regulation (induction) of BGLAP in osteoblast associated with osteoporosis
14) Confidence 0.11 Published 2010 Journal Journal of Indian Society of Periodontology Section Abstract Doc Link PMC2933523 Disease Relevance 0.28 Pain Relevance 0
The results of real-time PCR showed that after one week of treatment, compared to the control cells, the osteogenic transcription factors RUNX2 and two bone-related genes BGLAP and SPP1 were upregulated.
Positive_regulation (upregulated) of BGLAP
15) Confidence 0.11 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.15 Pain Relevance 0.07
Several authors reported that glucocorticoid-induced osteoporosis is reversible.8,91 Patients with Cushing syndrome had a restoration of osteoblast activity, evaluated on the basis of increased osteocalcin levels, after 6 months of disease cure, without achieving any relevant changes in bone mineral density (BMD).
Positive_regulation (increased) of osteocalcin in osteoblast associated with osteoporosis and disease
16) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.90 Pain Relevance 0.06

General Comments

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