INT184304

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.16
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bglap) cytoplasm (Bglap)
Bglap (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 38 99.76 Very High Very High Very High
rheumatoid arthritis 25 98.76 Very High Very High Very High
cytokine 4 69.84 Quite High
corticosteroid 1 59.32 Quite High
Intracerebroventricular 12 58.72 Quite High
Inflammation 15 56.20 Quite High
imagery 12 25.84 Quite Low
tolerance 9 5.00 Very Low Very Low Very Low
Clonidine 6 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 65 99.76 Very High Very High Very High
Rheumatoid Arthritis 25 98.76 Very High Very High Very High
Peritonitis 6 96.96 Very High Very High Very High
Osteoporosis 37 95.04 Very High Very High Very High
Endometriosis (extended) 3 93.08 High High
Obesity 87 91.20 High High
Hypercalcemia 8 87.16 High High
Necrosis 2 70.44 Quite High
Cancer 2 70.08 Quite High
Insulin Resistance 9 67.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we show that one important mechanism whereby leptin inhibits insulin secretion is by inhibiting the bioactivity of osteocalcin.
osteocalcin Binding (bioactivity) of
1) Confidence 0.31 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.44 Pain Relevance 0
In contrast to osteocalcin, leptin inhibits insulin secretion in part through a direct effect on ?
osteocalcin Binding (contrast) of
2) Confidence 0.31 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.26 Pain Relevance 0
Accordingly, and although the serum level of total osteocalcin was normal (Fig. 3 B), the amount of osteocalcin binding to hydroxyapatite (HA) with low affinity, i.e., undercarboxylated and biologically active (Lee et al., 2007), was increased in both ob/ob and Adr?
osteocalcin Binding (binding) of
3) Confidence 0.29 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0 Pain Relevance 0.03
Virulence and biofilm comparisons of OG1RF with V583
OG1RF Binding (Virulence) of
4) Confidence 0.17 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.16 Pain Relevance 0
In contrast to what Garnero and colleagues found in RA patients, we failed to demonstrate decreased serum levels of osteocalcin associated with arthritis.
osteocalcin Binding (associated) of associated with rheumatoid arthritis and arthritis
5) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.30 Pain Relevance 0.34

General Comments

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