INT184305

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 53
Total Number 58
Disease Relevance 31.66
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
tendon 15
skeletal muscle 9
ligament 7
cartilage 5
muscle 4
Comp (Mus musculus)
Comp - T585M (3)
Pain Link Frequency Relevance Heat
Arthritis 492 99.96 Very High Very High Very High
Inflammation 171 96.36 Very High Very High Very High
Pain 49 91.00 High High
rheumatoid arthritis 191 80.40 Quite High
agonist 58 76.88 Quite High
Osteoarthritis 182 68.64 Quite High
antagonist 15 57.28 Quite High
Inflammatory response 8 50.00 Quite Low
cytokine 54 45.36 Quite Low
chemokine 16 24.80 Low Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 98 99.96 Very High Very High Very High
Arthritis 567 99.68 Very High Very High Very High
Immunization 45 99.52 Very High Very High Very High
Muscle Disease 1379 99.34 Very High Very High Very High
Stress 1043 99.06 Very High Very High Very High
Osteoarthritis 301 97.64 Very High Very High Very High
Targeted Disruption 87 97.40 Very High Very High Very High
Muscle Weakness 511 96.96 Very High Very High Very High
Osteochondrodysplasias 1827 96.76 Very High Very High Very High
INFLAMMATION 168 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also confirmed that COMP was present in the ECM of skeletal muscle, specifically in the endo- and perimysium, and that there were no differences in its localization between wild-type and mutant tissues.
Gene_expression (present) of COMP in skeletal muscle
1) Confidence 0.77 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.51 Pain Relevance 0
On the basis of our previous findings in the mutant cartilage growth plate, where BiP was significantly upregulated and Bcl-2 was downregulated (20) owing to the expression of mutant Comp T585M, we considered the possibility that the expression of mutant Comp T585M was eliciting an rER/cell stress response in tenocytes that might eventually be causing increased cell death.
Gene_expression (expression) of Comp (T585M) in growth plate associated with stress and death
2) Confidence 0.77 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.63 Pain Relevance 0
In summary, we have shown that COMP is expressed in the Achilles tendon and skeletal muscle of adult mice.
Gene_expression (expressed) of COMP in tendon
3) Confidence 0.77 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.95 Pain Relevance 0.09
Although we demonstrated that COMP is expressed in skeletal muscle tissue, a quantifiable pathology was only apparent at the perimysial and MTJ of mutant muscle.
Gene_expression (expressed) of COMP in muscle
4) Confidence 0.77 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.24 Pain Relevance 0
The relative levels of Comp expression were also determined in Achilles tendon, spinal ligament, skeletal muscle and epiphyseal cartilage at 3 weeks of age (Supplementary Material, Table S2).
Gene_expression (expression) of Comp in tendon
5) Confidence 0.77 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0 Pain Relevance 0
COMP was expressed throughout skeletal muscle and tendon, yet the mutation resulted in a localised myopathy and a generalised tendinopathy.
Gene_expression (expressed) of COMP in skeletal muscle associated with muscle disease and tendinopathy
6) Confidence 0.75 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.29 Pain Relevance 0
Comp is expressed in murine tendon, ligament and skeletal muscle
Gene_expression (expressed) of Comp in ligament
7) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.38 Pain Relevance 0
There was no difference in Comp expression between wild-type and mutant samples in all of the tissues studied (data not shown).
Gene_expression (expression) of Comp
8) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0 Pain Relevance 0
We have shown that Comp is expressed in murine tendon and ligament by a variety of techniques, and that the localization of mutant COMP was not altered in mutant tissues.
Gene_expression (expressed) of Comp in tendon
9) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.34 Pain Relevance 0
These data therefore suggested that the expression of the Comp mutation per se did not have a generalized effect on the myocytes of skeletal muscle.


Gene_expression (expression) of Comp in skeletal muscle
10) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.39 Pain Relevance 0
Not surprisingly, Comp expression was lower in tissue samples from Achilles tendon, spinal ligament and skeletal muscle relative to the positive marker (Col1a1).
Gene_expression (expression) of Comp in tendon
11) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.06 Pain Relevance 0
These data suggest that either the expression levels of mutant COMP may not be high enough in tenocytes to elicit a classical rER stress response, or that tenocytes may respond differently to the expression of mutant COMP, which has been proposed previously (24).
Gene_expression (expression) of COMP associated with stress
12) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.77 Pain Relevance 0
These data suggest that either the expression levels of mutant COMP may not be high enough in tenocytes to elicit a classical rER stress response, or that tenocytes may respond differently to the expression of mutant COMP, which has been proposed previously (24).
Gene_expression (expression) of COMP associated with stress
13) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.70 Pain Relevance 0
In both wild-type and mutant tendon, COMP was present in the ECM between individual collagen fibrils (Fig. 3A; data not shown), confirming previous studies (35,36).
Gene_expression (present) of COMP in tendon
14) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.07 Pain Relevance 0
We have previously shown that mild ER stress was detected in chondrocytes from mutant mice expressing Comp T585M.
Gene_expression (expressing) of Comp (T585M) in chondrocytes associated with stress
15) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.48 Pain Relevance 0
The levels of Comp expression were comparable for tendon, ligament and skeletal muscle, whereas Comp expression was significantly higher in cartilage when compared with tendon, ligament and muscle samples (P < 0.05 by independent samples t-test, n = 3).
Gene_expression (expression) of Comp in ligament
16) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0 Pain Relevance 0
Nevertheless, Comp was still expressed in all of these tissues at levels >10-fold higher than the negative controls (Supplementary Material, Table S1).
Gene_expression (expressed) of Comp
17) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.06 Pain Relevance 0
On the basis of our previous findings in the mutant cartilage growth plate, where BiP was significantly upregulated and Bcl-2 was downregulated (20) owing to the expression of mutant Comp T585M, we considered the possibility that the expression of mutant Comp T585M was eliciting an rER/cell stress response in tenocytes that might eventually be causing increased cell death.
Gene_expression (expression) of Comp (T585M) in growth plate associated with stress and death
18) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.68 Pain Relevance 0
Comp is known to be expressed in skeletal muscle in mice (9); however, conflicting data exist concerning its expression in tendon with reports of either its presence (9) or absence (34) in adult murine Achilles tendon.
Gene_expression (expressed) of Comp in tendon
19) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.38 Pain Relevance 0
Therefore, before studying further the pathomolecular mechanisms of myopathy in the mutant mice, we undertook a detailed analysis of Comp expression in the relevant murine tissues (i.e. those of the musculoskeletal system).
Gene_expression (expression) of Comp in musculoskeletal system associated with muscle disease
20) Confidence 0.67 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.34 Pain Relevance 0

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