INT184306

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 5.10
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
muscle 4
cartilage 3
ligament 1
tendon 1
skeletal muscle 1
Comp (Mus musculus)
Comp - T585M (3)
Pain Link Frequency Relevance Heat
Arthritis 48 99.92 Very High Very High Very High
rheumatoid arthritis 25 35.52 Quite Low
Inflammation 15 9.20 Low Low
cytokine 4 8.16 Low Low
Osteoarthritis 40 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscle Disease 290 100.00 Very High Very High Very High
Muscle Weakness 110 99.92 Very High Very High Very High
Arthritis 75 99.92 Very High Very High Very High
Stress 240 96.80 Very High Very High Very High
Apoptosis 30 95.20 Very High Very High Very High
Tendinopathy 50 82.36 Quite High
Hypercalcemia 8 77.76 Quite High
Osteochondrodysplasias 390 60.52 Quite High
Cleidocranial Dysplasia 100 57.52 Quite High
Necrosis 2 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Localization (localization) of COMP in muscle
1) Confidence 0.69 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.42 Pain Relevance 0
We have shown that Comp is expressed in murine tendon and ligament by a variety of techniques, and that the localization of mutant COMP was not altered in mutant tissues.
Localization (localization) of COMP in ligament
2) Confidence 0.65 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.22 Pain Relevance 0
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Localization (presence) of COMP in muscle
3) Confidence 0.65 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.46 Pain Relevance 0
Overall, these data suggest that although secreted by myocytes and present in the ECM, mutant COMP did not have an effect on general skeletal muscle architecture and did not elicit an ER stress response in the mutant cells.
Localization (secreted) of COMP in skeletal muscle associated with stress
4) Confidence 0.65 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.48 Pain Relevance 0
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Localization (localization) of Comp (T585M) in muscle
5) Confidence 0.65 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.48 Pain Relevance 0
Muscle weakness in Comp T585M mice results from a mild myopathy localized to the perimysium and the MTJ
Localization (localized) of Comp (T585M) in Muscle associated with muscle disease and muscle weakness
6) Confidence 0.61 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.84 Pain Relevance 0
COMP is an extracellular matrix protein initially found in cartilage but recently also shown to be secreted by synovial fibroblasts.
Localization (secreted) of COMP in extracellular matrix
7) Confidence 0.59 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 0.61 Pain Relevance 0.12
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Localization (localization) of COMP in cartilage
8) Confidence 0.24 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.42 Pain Relevance 0
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Localization (localization) of Comp (T585M) in cartilage
9) Confidence 0.22 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.48 Pain Relevance 0
We have shown that Comp is expressed in murine tendon and ligament by a variety of techniques, and that the localization of mutant COMP was not altered in mutant tissues.
Localization (localization) of COMP in tendon
10) Confidence 0.22 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.22 Pain Relevance 0
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Localization (presence) of COMP in cartilage
11) Confidence 0.22 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.46 Pain Relevance 0

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