INT184307

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.48
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
ligament 4
cartilage 4
growth plate 2
tendon 1
muscle 1
Comp (Mus musculus)
Comp - T585M (1)
Pain Link Frequency Relevance Heat
Arthritis 124 99.96 Very High Very High Very High
Inflammation 57 96.36 Very High Very High Very High
agonist 28 76.88 Quite High
rheumatoid arthritis 37 50.56 Quite High
Inflammatory response 4 50.00 Quite Low
cytokine 19 34.72 Quite Low
chemokine 8 25.92 Quite Low
Osteoarthritis 16 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 49 99.96 Very High Very High Very High
Arthritis 110 99.68 Very High Very High Very High
INFLAMMATION 57 96.36 Very High Very High Very High
Stress 96 95.80 Very High Very High Very High
Death 8 92.72 High High
Apoptosis 12 92.48 High High
Hypercalcemia 9 67.04 Quite High
Osteoporosis 16 64.40 Quite High
Sprains And Strains 58 63.76 Quite High
Disease 29 62.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of our previous findings in the mutant cartilage growth plate, where BiP was significantly upregulated and Bcl-2 was downregulated (20) owing to the expression of mutant Comp T585M, we considered the possibility that the expression of mutant Comp T585M was eliciting an rER/cell stress response in tenocytes that might eventually be causing increased cell death.
Positive_regulation (owing) of Gene_expression (expression) of Comp (T585M) in growth plate associated with stress and death
1) Confidence 0.50 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.64 Pain Relevance 0
The levels of Comp expression were comparable for tendon, ligament and skeletal muscle, whereas Comp expression was significantly higher in cartilage when compared with tendon, ligament and muscle samples (P < 0.05 by independent samples t-test, n = 3).
Positive_regulation (higher) of Gene_expression (expression) of Comp in ligament
2) Confidence 0.40 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0 Pain Relevance 0
We found increased serum COMP levels in all arthritic mice, irrespective of the estrogen level, indicating a lack of cartilage protection by endogenous ovarian hormones.
Positive_regulation (increased) of Gene_expression (levels) of COMP in cartilage associated with arthritis
3) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 0.80 Pain Relevance 0.15
In CIA, serum COMP levels are increased due to enhanced cartilage destruction.
Positive_regulation (increased) of Gene_expression (levels) of serum COMP in cartilage associated with arthritis
4) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.05 Pain Relevance 0.44
The levels of Comp expression were comparable for tendon, ligament and skeletal muscle, whereas Comp expression was significantly higher in cartilage when compared with tendon, ligament and muscle samples (P < 0.05 by independent samples t-test, n = 3).
Positive_regulation (higher) of in muscle Gene_expression (expression) of Comp in ligament
5) Confidence 0.14 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0 Pain Relevance 0
The levels of Comp expression were comparable for tendon, ligament and skeletal muscle, whereas Comp expression was significantly higher in cartilage when compared with tendon, ligament and muscle samples (P < 0.05 by independent samples t-test, n = 3).
Positive_regulation (higher) of in tendon Gene_expression (expression) of Comp in ligament
6) Confidence 0.14 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0 Pain Relevance 0

General Comments

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